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Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions

Fibrils formed by the 42-residue amyloid-β peptide (Aβ42), a main component of amyloid deposits in Alzheimer's disease (AD), are known to be polymorphic, i.e., to contain multiple possible molecular structures. Previous studies of Aβ42 fibrils, including fibrils prepared entirely in vitro or ex...

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Detalles Bibliográficos
Autores principales:	Lee, Myungwoon, Yau, Wai-Ming, Louis, John M., Tycko, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089215/ https://www.ncbi.nlm.nih.gov/pubmed/36893281 http://dx.doi.org/10.1073/pnas.2218831120

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