A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation

Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across the plasma membrane. However, constitutive MRP1 function hinders drug delivery across the blood–brain barrier, and MRP...

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Detalles Bibliográficos
Autores principales: Pietz, Harlan L., Abbas, Ata, Johnson, Zachary Lee, Oldham, Michael L., Suga, Hiroaki, Chen, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089224/
https://www.ncbi.nlm.nih.gov/pubmed/36893260
http://dx.doi.org/10.1073/pnas.2220012120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089224/
https://www.ncbi.nlm.nih.gov/pubmed/36893260
http://dx.doi.org/10.1073/pnas.2220012120

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