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A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation

Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across the plasma membrane. However, constitutive MRP1 function hinders drug delivery across the blood–brain barrier, and MRP...

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Detalles Bibliográficos
Autores principales:	Pietz, Harlan L., Abbas, Ata, Johnson, Zachary Lee, Oldham, Michael L., Suga, Hiroaki, Chen, Jue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089224/ https://www.ncbi.nlm.nih.gov/pubmed/36893260 http://dx.doi.org/10.1073/pnas.2220012120

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