Computational design of BclxL inhibitors that target transmembrane domain interactions

Several methods have been developed to explore interactions among water-soluble proteins or regions of proteins. However, techniques to target transmembrane domains (TMDs) have not been examined thoroughly despite their importance. Here, we developed a computational approach to design sequences that...

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Detalles Bibliográficos
Autores principales: Duart, Gerard, Elazar, Assaf, Weinstein, Jonathan Y., Gadea-Salom, Laura, Ortiz-Mateu, Juan, Fleishman, Sarel J., Mingarro, Ismael, Martinez-Gil, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089226/
https://www.ncbi.nlm.nih.gov/pubmed/36881618
http://dx.doi.org/10.1073/pnas.2219648120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089226/
https://www.ncbi.nlm.nih.gov/pubmed/36881618
http://dx.doi.org/10.1073/pnas.2219648120

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