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Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible?
PURPOSE: Esophageal mucosal admittance (MA) is a promising diagnostic method for gastroesophageal reflux disease (GERD). We conducted a study to describe the esophageal MA in patients with reflux symptoms and determine its diagnostic accuracy. PATIENTS AND METHODS: We recruited 92 patients with ambu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089276/ https://www.ncbi.nlm.nih.gov/pubmed/37056486 http://dx.doi.org/10.2147/CEG.S399764 |
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author | Dao, Hang Viet Hoang, Long Bao Nguyen, Binh Phuc Nguyen, Hoa Lan Goldberg, Robert Allison, Jeroan Dao, Thi Minh An Matsumura, Tomoaki Dao, Long Van |
author_facet | Dao, Hang Viet Hoang, Long Bao Nguyen, Binh Phuc Nguyen, Hoa Lan Goldberg, Robert Allison, Jeroan Dao, Thi Minh An Matsumura, Tomoaki Dao, Long Van |
author_sort | Dao, Hang Viet |
collection | PubMed |
description | PURPOSE: Esophageal mucosal admittance (MA) is a promising diagnostic method for gastroesophageal reflux disease (GERD). We conducted a study to describe the esophageal MA in patients with reflux symptoms and determine its diagnostic accuracy. PATIENTS AND METHODS: We recruited 92 patients with ambulatory pH-impedance monitoring, upper gastrointestinal endoscopy, and MA measured by the tissue conductance meter. MA was measured during endoscopy at 5cm (distal esophagus) and 15cm above the Z line (middle esophagus), repeated at least five times at each position, and median MA was obtained. Afterwards, two biopsies were taken 5cm above the Z line for histopathological evaluation using the Esohisto criteria. Patients were classified as GERD or non-GERD according to the 2018 Lyon consensus. RESULTS: The mean age was 43.2 years, and 42 patients were males. The most common symptoms were regurgitation (75.0%), belching (65.2%), and heartburn (46.7%). Twenty-three (32.3%) were diagnosed with GERD using the Lyon consensus, and 24 (26.1%) had esophagitis on histopathology. The median MA at the distal and middle esophagus was moderately correlated. The median MA at both positions was higher in the GERD group but only statistically significant in the middle esophagus. MA was not associated with pH-impedance parameters and esophagitis on histopathology. The diagnostic model developed using the logistic regression did not have good accuracy. CONCLUSION: MA was not different between GERD and non-GERD patients. |
format | Online Article Text |
id | pubmed-10089276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-100892762023-04-12 Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? Dao, Hang Viet Hoang, Long Bao Nguyen, Binh Phuc Nguyen, Hoa Lan Goldberg, Robert Allison, Jeroan Dao, Thi Minh An Matsumura, Tomoaki Dao, Long Van Clin Exp Gastroenterol Original Research PURPOSE: Esophageal mucosal admittance (MA) is a promising diagnostic method for gastroesophageal reflux disease (GERD). We conducted a study to describe the esophageal MA in patients with reflux symptoms and determine its diagnostic accuracy. PATIENTS AND METHODS: We recruited 92 patients with ambulatory pH-impedance monitoring, upper gastrointestinal endoscopy, and MA measured by the tissue conductance meter. MA was measured during endoscopy at 5cm (distal esophagus) and 15cm above the Z line (middle esophagus), repeated at least five times at each position, and median MA was obtained. Afterwards, two biopsies were taken 5cm above the Z line for histopathological evaluation using the Esohisto criteria. Patients were classified as GERD or non-GERD according to the 2018 Lyon consensus. RESULTS: The mean age was 43.2 years, and 42 patients were males. The most common symptoms were regurgitation (75.0%), belching (65.2%), and heartburn (46.7%). Twenty-three (32.3%) were diagnosed with GERD using the Lyon consensus, and 24 (26.1%) had esophagitis on histopathology. The median MA at the distal and middle esophagus was moderately correlated. The median MA at both positions was higher in the GERD group but only statistically significant in the middle esophagus. MA was not associated with pH-impedance parameters and esophagitis on histopathology. The diagnostic model developed using the logistic regression did not have good accuracy. CONCLUSION: MA was not different between GERD and non-GERD patients. Dove 2023-04-07 /pmc/articles/PMC10089276/ /pubmed/37056486 http://dx.doi.org/10.2147/CEG.S399764 Text en © 2023 Dao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Dao, Hang Viet Hoang, Long Bao Nguyen, Binh Phuc Nguyen, Hoa Lan Goldberg, Robert Allison, Jeroan Dao, Thi Minh An Matsumura, Tomoaki Dao, Long Van Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? |
title | Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? |
title_full | Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? |
title_fullStr | Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? |
title_full_unstemmed | Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? |
title_short | Esophageal Mucosal Admittance: A New Technique to Diagnose Gastroesophageal Reflux Disease – Is It Feasible? |
title_sort | esophageal mucosal admittance: a new technique to diagnose gastroesophageal reflux disease – is it feasible? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089276/ https://www.ncbi.nlm.nih.gov/pubmed/37056486 http://dx.doi.org/10.2147/CEG.S399764 |
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