Well-Defined Heparin Mimetics Can Inhibit Binding of the Trimeric Spike of SARS-CoV-2 in a Length-Dependent Manner

[Image: see text] The emergence of new SARS-CoV-2 variants and the dangers of long-covid necessitate the development of broad-acting therapeutics that can reduce viral burden. SARS-CoV-2 employs heparan sulfate (HS) as an initial cellular attachment factor, and therefore, there is interest in develo...

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Detalles Bibliográficos
Autores principales: Sun, Lifeng, Chopra, Pradeep, Tomris, Ilhan, van der Woude, Roosmarijn, Liu, Lin, de Vries, Robert P., Boons, Geert-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089289/
https://www.ncbi.nlm.nih.gov/pubmed/37101566
http://dx.doi.org/10.1021/jacsau.3c00042

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