Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice

Osteocalcin (Ocn), also known as bone Gla protein, is synthesized by osteoblasts and thought to regulate energy metabolism, testosterone synthesis and brain development. However, its function in bone is not fully understood. Mice have three Ocn genes: Bglap, Bglap2 and Bglap3. Due to the long span o...

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Detalles Bibliográficos
Autores principales: Xu, Zihan, Yang, Chao, Wu, Feng, Tan, Xiaowen, Guo, Yaxiu, Zhang, Hongyu, Wang, Hailong, Sui, Xiukun, Xu, Zi, Zhao, Minbo, Jiang, Siyu, Dai, Zhongquan, Li, Yinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089303/
https://www.ncbi.nlm.nih.gov/pubmed/37057181
http://dx.doi.org/10.3389/fphys.2023.1136561

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