A randomized, controlled Phase 1b trial of the Sm-TSP-2 Vaccine for intestinal schistosomiasis in healthy Brazilian adults living in an endemic area

BACKGROUND: Recombinant Schistosoma mansoni Tetraspanin-2 formulated on Alhydrogel (Sm-TSP-2/Alhydrogel) is being developed to prevent intestinal and hepatic disease caused by S. mansoni. The tegumentary Sm-TSP-2 antigen was selected based on its unique recognition by cytophilic antibodies in putati...

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Detalles Bibliográficos
Autores principales: Diemert, David J., Correa-Oliveira, Rodrigo, Fraga, Carlo Geraldo, Talles, Frederico, Silva, Marcella Rezende, Patel, Shital M., Galbiati, Shirley, Kennedy, Jessie K., Lundeen, Jordan S., Gazzinelli, Maria Flavia, Li, Guangzhao, Hoeweler, Lara, Deye, Gregory A., Bottazzi, Maria Elena, Hotez, Peter J., El Sahly, Hana M., Keitel, Wendy A., Bethony, Jeffrey, Atmar, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089325/
https://www.ncbi.nlm.nih.gov/pubmed/36996185
http://dx.doi.org/10.1371/journal.pntd.0011236

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