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Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas
The SARS-CoV-2 variants of concern (VOCs) Delta and Omicron spread globally during mid and late 2021, respectively. In this study, we compare the dissemination dynamics of these VOCs in the Amazonas state, one of Brazil’s most heavily affected regions. We sequenced the virus genome from 4128 patient...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089528/ https://www.ncbi.nlm.nih.gov/pubmed/37041143 http://dx.doi.org/10.1038/s41467-023-37541-6 |
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| author | Arantes, Ighor Bello, Gonzalo Nascimento, Valdinete Souza, Victor da Silva, Arlesson Silva, Dejanane Nascimento, Fernanda Mejía, Matilde Brandão, Maria Júlia Gonçalves, Luciana Silva, George da Costa, Cristiano Fernandes Abdalla, Ligia Santos, João Hugo Ramos, Tatyana Costa Amorim Piantham, Chayada Ito, Kimihito Siqueira, Marilda Mendonça Resende, Paola Cristina Wallau, Gabriel Luz Delatorre, Edson Gräf, Tiago Naveca, Felipe Gomes |
| author_facet | Arantes, Ighor Bello, Gonzalo Nascimento, Valdinete Souza, Victor da Silva, Arlesson Silva, Dejanane Nascimento, Fernanda Mejía, Matilde Brandão, Maria Júlia Gonçalves, Luciana Silva, George da Costa, Cristiano Fernandes Abdalla, Ligia Santos, João Hugo Ramos, Tatyana Costa Amorim Piantham, Chayada Ito, Kimihito Siqueira, Marilda Mendonça Resende, Paola Cristina Wallau, Gabriel Luz Delatorre, Edson Gräf, Tiago Naveca, Felipe Gomes |
| author_sort | Arantes, Ighor |
| collection | PubMed |
| description | The SARS-CoV-2 variants of concern (VOCs) Delta and Omicron spread globally during mid and late 2021, respectively. In this study, we compare the dissemination dynamics of these VOCs in the Amazonas state, one of Brazil’s most heavily affected regions. We sequenced the virus genome from 4128 patients collected in Amazonas between July 1st, 2021, and January 31st, 2022, and investigated the viral dynamics using a phylodynamic approach. The VOCs Delta and Omicron BA.1 displayed similar patterns of phylogeographic spread but different epidemic dynamics. The replacement of Gamma by Delta was gradual and occurred without an upsurge of COVID-19 cases, while the rise of Omicron BA.1 was extremely fast and fueled a sharp increase in cases. Thus, the dissemination dynamics and population-level impact of new SARS-CoV-2 variants introduced in the Amazonian population after mid-2021, a setting with high levels of acquired immunity, greatly vary according to their viral phenotype. |
| format | Online Article Text |
| id | pubmed-10089528 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100895282023-04-12 Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas Arantes, Ighor Bello, Gonzalo Nascimento, Valdinete Souza, Victor da Silva, Arlesson Silva, Dejanane Nascimento, Fernanda Mejía, Matilde Brandão, Maria Júlia Gonçalves, Luciana Silva, George da Costa, Cristiano Fernandes Abdalla, Ligia Santos, João Hugo Ramos, Tatyana Costa Amorim Piantham, Chayada Ito, Kimihito Siqueira, Marilda Mendonça Resende, Paola Cristina Wallau, Gabriel Luz Delatorre, Edson Gräf, Tiago Naveca, Felipe Gomes Nat Commun Article The SARS-CoV-2 variants of concern (VOCs) Delta and Omicron spread globally during mid and late 2021, respectively. In this study, we compare the dissemination dynamics of these VOCs in the Amazonas state, one of Brazil’s most heavily affected regions. We sequenced the virus genome from 4128 patients collected in Amazonas between July 1st, 2021, and January 31st, 2022, and investigated the viral dynamics using a phylodynamic approach. The VOCs Delta and Omicron BA.1 displayed similar patterns of phylogeographic spread but different epidemic dynamics. The replacement of Gamma by Delta was gradual and occurred without an upsurge of COVID-19 cases, while the rise of Omicron BA.1 was extremely fast and fueled a sharp increase in cases. Thus, the dissemination dynamics and population-level impact of new SARS-CoV-2 variants introduced in the Amazonian population after mid-2021, a setting with high levels of acquired immunity, greatly vary according to their viral phenotype. Nature Publishing Group UK 2023-04-11 /pmc/articles/PMC10089528/ /pubmed/37041143 http://dx.doi.org/10.1038/s41467-023-37541-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Arantes, Ighor Bello, Gonzalo Nascimento, Valdinete Souza, Victor da Silva, Arlesson Silva, Dejanane Nascimento, Fernanda Mejía, Matilde Brandão, Maria Júlia Gonçalves, Luciana Silva, George da Costa, Cristiano Fernandes Abdalla, Ligia Santos, João Hugo Ramos, Tatyana Costa Amorim Piantham, Chayada Ito, Kimihito Siqueira, Marilda Mendonça Resende, Paola Cristina Wallau, Gabriel Luz Delatorre, Edson Gräf, Tiago Naveca, Felipe Gomes Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas |
| title | Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas |
| title_full | Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas |
| title_fullStr | Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas |
| title_full_unstemmed | Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas |
| title_short | Comparative epidemic expansion of SARS-CoV-2 variants Delta and Omicron in the Brazilian State of Amazonas |
| title_sort | comparative epidemic expansion of sars-cov-2 variants delta and omicron in the brazilian state of amazonas |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089528/ https://www.ncbi.nlm.nih.gov/pubmed/37041143 http://dx.doi.org/10.1038/s41467-023-37541-6 |
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