Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing

It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H(2) is an emerging energy-regulating molecule possessing both high biosafety and hi...

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Autores principales: Xu, Qingqing, Chen, Shengqiang, Jiang, Lingdong, Xia, Chao, Zeng, Lingting, Cai, Xiaoqing, Jin, Zhaokui, Qin, Shucun, Ding, Wenjiang, He, Qianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089581/
https://www.ncbi.nlm.nih.gov/pubmed/37056424
http://dx.doi.org/10.1093/nsr/nwad063
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author Xu, Qingqing
Chen, Shengqiang
Jiang, Lingdong
Xia, Chao
Zeng, Lingting
Cai, Xiaoqing
Jin, Zhaokui
Qin, Shucun
Ding, Wenjiang
He, Qianjun
author_facet Xu, Qingqing
Chen, Shengqiang
Jiang, Lingdong
Xia, Chao
Zeng, Lingting
Cai, Xiaoqing
Jin, Zhaokui
Qin, Shucun
Ding, Wenjiang
He, Qianjun
author_sort Xu, Qingqing
collection PubMed
description It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H(2) is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability. In this work, we propose a concept of sonocatalytic hydrogen/hole-combined ‘inside/outside-cooperation’ anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials. Proof-of-concept experiments using C(3)N(4) nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H(2) and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain, respectively, inside/outside-cooperatively eradicating biofilm. A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy, remarkably improving bacteria-infected diabetic wound healing. The proposed strategy of sonocatalytic hole/hydrogen-combined ‘inside/outside-cooperation’ will make a highway for treatment of deep-seated biofilm infection.
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spelling pubmed-100895812023-04-12 Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing Xu, Qingqing Chen, Shengqiang Jiang, Lingdong Xia, Chao Zeng, Lingting Cai, Xiaoqing Jin, Zhaokui Qin, Shucun Ding, Wenjiang He, Qianjun Natl Sci Rev Research Article It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H(2) is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability. In this work, we propose a concept of sonocatalytic hydrogen/hole-combined ‘inside/outside-cooperation’ anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials. Proof-of-concept experiments using C(3)N(4) nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H(2) and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain, respectively, inside/outside-cooperatively eradicating biofilm. A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy, remarkably improving bacteria-infected diabetic wound healing. The proposed strategy of sonocatalytic hole/hydrogen-combined ‘inside/outside-cooperation’ will make a highway for treatment of deep-seated biofilm infection. Oxford University Press 2023-03-06 /pmc/articles/PMC10089581/ /pubmed/37056424 http://dx.doi.org/10.1093/nsr/nwad063 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xu, Qingqing
Chen, Shengqiang
Jiang, Lingdong
Xia, Chao
Zeng, Lingting
Cai, Xiaoqing
Jin, Zhaokui
Qin, Shucun
Ding, Wenjiang
He, Qianjun
Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
title Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
title_full Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
title_fullStr Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
title_full_unstemmed Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
title_short Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
title_sort sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089581/
https://www.ncbi.nlm.nih.gov/pubmed/37056424
http://dx.doi.org/10.1093/nsr/nwad063
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