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Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces
Biocompatible field-effect-transistor-based biosensors have drawn attention for the development of next-generation human-friendly electronics. High-performance electronic devices must achieve low-voltage operation, long-term operational stability, and biocompatibility. Herein, we propose an electrol...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089684/ https://www.ncbi.nlm.nih.gov/pubmed/37056513 http://dx.doi.org/10.1063/5.0138861 |
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author | Kang, Dong-Hee Choi, Jun-Gyu Lee, Won-June Heo, Dongmi Wang, Sungrok Park, Sungjun Yoon, Myung-Han |
author_facet | Kang, Dong-Hee Choi, Jun-Gyu Lee, Won-June Heo, Dongmi Wang, Sungrok Park, Sungjun Yoon, Myung-Han |
author_sort | Kang, Dong-Hee |
collection | PubMed |
description | Biocompatible field-effect-transistor-based biosensors have drawn attention for the development of next-generation human-friendly electronics. High-performance electronic devices must achieve low-voltage operation, long-term operational stability, and biocompatibility. Herein, we propose an electrolyte-gated thin-film transistor made of large-area solution-processed indium–gallium–zinc oxide (IGZO) semiconductors capable of directly interacting with live cells at physiological conditions. The fabricated transistors exhibit good electrical performance operating under sub-0.5 V conditions with high on-/off-current ratios (>10(7)) and transconductance (>1.0 mS) over an extended operational lifetime. Furthermore, we verified the biocompatibility of the IGZO surface to various types of mammalian cells in terms of cell viability, proliferation, morphology, and drug responsiveness. Finally, the prolonged stable operation of electrolyte-gated transistor devices directly integrated with live cells provides the proof-of-concept for solution-processed metal oxide material-based direct cellular interfaces. |
format | Online Article Text |
id | pubmed-10089684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-100896842023-04-12 Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces Kang, Dong-Hee Choi, Jun-Gyu Lee, Won-June Heo, Dongmi Wang, Sungrok Park, Sungjun Yoon, Myung-Han APL Bioeng Articles Biocompatible field-effect-transistor-based biosensors have drawn attention for the development of next-generation human-friendly electronics. High-performance electronic devices must achieve low-voltage operation, long-term operational stability, and biocompatibility. Herein, we propose an electrolyte-gated thin-film transistor made of large-area solution-processed indium–gallium–zinc oxide (IGZO) semiconductors capable of directly interacting with live cells at physiological conditions. The fabricated transistors exhibit good electrical performance operating under sub-0.5 V conditions with high on-/off-current ratios (>10(7)) and transconductance (>1.0 mS) over an extended operational lifetime. Furthermore, we verified the biocompatibility of the IGZO surface to various types of mammalian cells in terms of cell viability, proliferation, morphology, and drug responsiveness. Finally, the prolonged stable operation of electrolyte-gated transistor devices directly integrated with live cells provides the proof-of-concept for solution-processed metal oxide material-based direct cellular interfaces. AIP Publishing LLC 2023-04-10 /pmc/articles/PMC10089684/ /pubmed/37056513 http://dx.doi.org/10.1063/5.0138861 Text en © 2023 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Articles Kang, Dong-Hee Choi, Jun-Gyu Lee, Won-June Heo, Dongmi Wang, Sungrok Park, Sungjun Yoon, Myung-Han Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
title | Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
title_full | Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
title_fullStr | Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
title_full_unstemmed | Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
title_short | Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
title_sort | aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089684/ https://www.ncbi.nlm.nih.gov/pubmed/37056513 http://dx.doi.org/10.1063/5.0138861 |
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