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XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death

XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn’s disease, or those needing allogeneic hematopoietic cell transplantation, is associa...

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Detalles Bibliográficos
Autores principales:	Witt, Axel, Goncharov, Tatiana, Lee, Yujung Michelle, Kist, Matthias, Dohse, Monika, Eastham, Jeff, Dugger, Debra, Newton, Kim, Webster, Joshua D., Vucic, Domagoj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090100/ https://www.ncbi.nlm.nih.gov/pubmed/37041175 http://dx.doi.org/10.1038/s41419-023-05793-1

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