A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

Type I interferons (IFNs) are consequential cytokines in antibacterial defense. Whether and how bacterial pathogens inhibit innate immune receptor-driven type I IFN expression remains mostly unknown. By screening a library of enterohemorrhagic Escherichia coli (EHEC) mutants, we uncovered EhaF, an u...

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Detalles Bibliográficos
Autores principales: Ta, Atri, Ricci-Azevedo, Rafael, Vasudevan, Swathy O., Wright, Skylar S., Kumari, Puja, Havira, Morena S., Surendran Nair, Meera, Rathinam, Vijay A., Vanaja, Sivapriya Kailasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090168/
https://www.ncbi.nlm.nih.gov/pubmed/37041208
http://dx.doi.org/10.1038/s41467-023-37812-2

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