Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy

Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate cancer. Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a STEA...

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Detalles Bibliográficos
Autores principales: Bhatia, Vipul, Kamat, Nikhil V., Pariva, Tiffany E., Wu, Li-Ting, Tsao, Annabelle, Sasaki, Koichi, Sun, Huiyun, Javier, Gerardo, Nutt, Sam, Coleman, Ilsa, Hitchcock, Lauren, Zhang, Ailin, Rudoy, Dmytro, Gulati, Roman, Patel, Radhika A., Roudier, Martine P., True, Lawrence D., Srivastava, Shivani, Morrissey, Colm M., Haffner, Michael C., Nelson, Peter S., Priceman, Saul J., Ishihara, Jun, Lee, John K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090190/
https://www.ncbi.nlm.nih.gov/pubmed/37041154
http://dx.doi.org/10.1038/s41467-023-37874-2

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