Cargando…

Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans

INTRODUCTION: South Asians (SAs) have an elevated risk of cardiovascular disease (CVD) compared with White Europeans (WEs). Postprandial endothelial function (flow-mediated dilatation (FMD%)) in SA women and SA men with central obesity has not been investigated. Research in other populations has hig...

Descripción completa

Detalles Bibliográficos
Autores principales: ROBERTS, MATTHEW J., THACKRAY, ALICE E., WADLEY, ALEX J., ALOTAIBI, TAREQ F., HUNTER, DAVID J., THOMPSON, JULIE, FUJIHIRA, KYOKO, MIYASHITA, MASASHI, MASTANA, SARABJIT, BISHOP, NICOLETTE C., O’DONNELL, EMMA, DAVIES, MELANIE J., KING, JAMES A., YATES, THOMAS, WEBB, DAVID, STENSEL, DAVID J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090289/
https://www.ncbi.nlm.nih.gov/pubmed/36729923
http://dx.doi.org/10.1249/MSS.0000000000003098
_version_ 1785022929344397312
author ROBERTS, MATTHEW J.
THACKRAY, ALICE E.
WADLEY, ALEX J.
ALOTAIBI, TAREQ F.
HUNTER, DAVID J.
THOMPSON, JULIE
FUJIHIRA, KYOKO
MIYASHITA, MASASHI
MASTANA, SARABJIT
BISHOP, NICOLETTE C.
O’DONNELL, EMMA
DAVIES, MELANIE J.
KING, JAMES A.
YATES, THOMAS
WEBB, DAVID
STENSEL, DAVID J.
author_facet ROBERTS, MATTHEW J.
THACKRAY, ALICE E.
WADLEY, ALEX J.
ALOTAIBI, TAREQ F.
HUNTER, DAVID J.
THOMPSON, JULIE
FUJIHIRA, KYOKO
MIYASHITA, MASASHI
MASTANA, SARABJIT
BISHOP, NICOLETTE C.
O’DONNELL, EMMA
DAVIES, MELANIE J.
KING, JAMES A.
YATES, THOMAS
WEBB, DAVID
STENSEL, DAVID J.
author_sort ROBERTS, MATTHEW J.
collection PubMed
description INTRODUCTION: South Asians (SAs) have an elevated risk of cardiovascular disease (CVD) compared with White Europeans (WEs). Postprandial endothelial function (flow-mediated dilatation (FMD%)) in SA women and SA men with central obesity has not been investigated. Research in other populations has highlighted that a 1% higher FMD% is associated with a ~13% lower risk of future CVD events. We investigated whether FMD% and lipemia, two markers for CVD risk, were higher in SAs versus WEs, whether walking improved FMD% and lipemia, and if there were ethnic differences in the response. METHODS: Lean premenopausal women (study 1; 12 SA, 12 WE) and men with central obesity (study 2; 15 SA, 15 WE) completed two 2-d trials. On day 1, participants walked for 60 min at 60% of their peak oxygen uptake or rested. On day 2, participants rested and consumed two high-fat meals over 8 h. Repeated ultrasound assessments of endothelial function and venous blood samples for CVD risk markers were taken. RESULTS: Compared with WEs, SAs had lower postprandial FMD% (study 1, −1.32%; study 2, −0.54%) and higher postprandial triacylglycerol concentrations (study 1, 0.31 mmol·L(−1)·h(−1); study 2, 0.55 mmol·L(−1)·h(−1)). Walking improved postprandial FMD% (study 1, 1.12%; study 2, 0.94%) and resulted in no significant change or small reductions in postprandial triacylglycerol concentrations (study 1, −0.01 mmol·L(−1)·h(−1); study 2, −0.25 mmol·L(−1)·h(−1)). Exercise-induced changes in FMD% and triacylglycerol were consistent between ethnic groups. CONCLUSIONS: Walking mitigated the adverse postprandial effect of a high-fat diet on FMD% to a similar extent in SA and WE women and men, even with no/small improvements in triacylglycerol. This study highlights the importance of exercise to clinically improve FMD% in SAs and WEs.
format Online
Article
Text
id pubmed-10090289
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-100902892023-04-13 Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans ROBERTS, MATTHEW J. THACKRAY, ALICE E. WADLEY, ALEX J. ALOTAIBI, TAREQ F. HUNTER, DAVID J. THOMPSON, JULIE FUJIHIRA, KYOKO MIYASHITA, MASASHI MASTANA, SARABJIT BISHOP, NICOLETTE C. O’DONNELL, EMMA DAVIES, MELANIE J. KING, JAMES A. YATES, THOMAS WEBB, DAVID STENSEL, DAVID J. Med Sci Sports Exerc Basic Sciences INTRODUCTION: South Asians (SAs) have an elevated risk of cardiovascular disease (CVD) compared with White Europeans (WEs). Postprandial endothelial function (flow-mediated dilatation (FMD%)) in SA women and SA men with central obesity has not been investigated. Research in other populations has highlighted that a 1% higher FMD% is associated with a ~13% lower risk of future CVD events. We investigated whether FMD% and lipemia, two markers for CVD risk, were higher in SAs versus WEs, whether walking improved FMD% and lipemia, and if there were ethnic differences in the response. METHODS: Lean premenopausal women (study 1; 12 SA, 12 WE) and men with central obesity (study 2; 15 SA, 15 WE) completed two 2-d trials. On day 1, participants walked for 60 min at 60% of their peak oxygen uptake or rested. On day 2, participants rested and consumed two high-fat meals over 8 h. Repeated ultrasound assessments of endothelial function and venous blood samples for CVD risk markers were taken. RESULTS: Compared with WEs, SAs had lower postprandial FMD% (study 1, −1.32%; study 2, −0.54%) and higher postprandial triacylglycerol concentrations (study 1, 0.31 mmol·L(−1)·h(−1); study 2, 0.55 mmol·L(−1)·h(−1)). Walking improved postprandial FMD% (study 1, 1.12%; study 2, 0.94%) and resulted in no significant change or small reductions in postprandial triacylglycerol concentrations (study 1, −0.01 mmol·L(−1)·h(−1); study 2, −0.25 mmol·L(−1)·h(−1)). Exercise-induced changes in FMD% and triacylglycerol were consistent between ethnic groups. CONCLUSIONS: Walking mitigated the adverse postprandial effect of a high-fat diet on FMD% to a similar extent in SA and WE women and men, even with no/small improvements in triacylglycerol. This study highlights the importance of exercise to clinically improve FMD% in SAs and WEs. Lippincott Williams & Wilkins 2023-05 2022-12-05 /pmc/articles/PMC10090289/ /pubmed/36729923 http://dx.doi.org/10.1249/MSS.0000000000003098 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Sciences
ROBERTS, MATTHEW J.
THACKRAY, ALICE E.
WADLEY, ALEX J.
ALOTAIBI, TAREQ F.
HUNTER, DAVID J.
THOMPSON, JULIE
FUJIHIRA, KYOKO
MIYASHITA, MASASHI
MASTANA, SARABJIT
BISHOP, NICOLETTE C.
O’DONNELL, EMMA
DAVIES, MELANIE J.
KING, JAMES A.
YATES, THOMAS
WEBB, DAVID
STENSEL, DAVID J.
Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
title Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
title_full Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
title_fullStr Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
title_full_unstemmed Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
title_short Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans
title_sort effect of acute walking on endothelial function and postprandial lipemia in south asians and white europeans
topic Basic Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090289/
https://www.ncbi.nlm.nih.gov/pubmed/36729923
http://dx.doi.org/10.1249/MSS.0000000000003098
work_keys_str_mv AT robertsmatthewj effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT thackrayalicee effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT wadleyalexj effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT alotaibitareqf effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT hunterdavidj effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT thompsonjulie effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT fujihirakyoko effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT miyashitamasashi effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT mastanasarabjit effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT bishopnicolettec effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT odonnellemma effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT daviesmelaniej effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT kingjamesa effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT yatesthomas effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT webbdavid effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans
AT stenseldavidj effectofacutewalkingonendothelialfunctionandpostprandiallipemiainsouthasiansandwhiteeuropeans