Cargando…
Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090296/ https://www.ncbi.nlm.nih.gov/pubmed/37063883 http://dx.doi.org/10.3389/fimmu.2023.1107266 |
_version_ | 1785022931022118912 |
---|---|
author | ElAbd, Hesham Bacher, Petra Tholey, Andreas Lenz, Tobias L. Franke, Andre |
author_facet | ElAbd, Hesham Bacher, Petra Tholey, Andreas Lenz, Tobias L. Franke, Andre |
author_sort | ElAbd, Hesham |
collection | PubMed |
description | The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies. |
format | Online Article Text |
id | pubmed-10090296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100902962023-04-13 Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins ElAbd, Hesham Bacher, Petra Tholey, Andreas Lenz, Tobias L. Franke, Andre Front Immunol Immunology The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090296/ /pubmed/37063883 http://dx.doi.org/10.3389/fimmu.2023.1107266 Text en Copyright © 2023 ElAbd, Bacher, Tholey, Lenz and Franke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology ElAbd, Hesham Bacher, Petra Tholey, Andreas Lenz, Tobias L. Franke, Andre Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins |
title | Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins |
title_full | Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins |
title_fullStr | Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins |
title_full_unstemmed | Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins |
title_short | Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins |
title_sort | challenges and opportunities in analyzing and modeling peptide presentation by hla-ii proteins |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090296/ https://www.ncbi.nlm.nih.gov/pubmed/37063883 http://dx.doi.org/10.3389/fimmu.2023.1107266 |
work_keys_str_mv | AT elabdhesham challengesandopportunitiesinanalyzingandmodelingpeptidepresentationbyhlaiiproteins AT bacherpetra challengesandopportunitiesinanalyzingandmodelingpeptidepresentationbyhlaiiproteins AT tholeyandreas challengesandopportunitiesinanalyzingandmodelingpeptidepresentationbyhlaiiproteins AT lenztobiasl challengesandopportunitiesinanalyzingandmodelingpeptidepresentationbyhlaiiproteins AT frankeandre challengesandopportunitiesinanalyzingandmodelingpeptidepresentationbyhlaiiproteins |