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A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection

HIV affects 36 million people globally with prevalence decreasing due to antiretroviral therapy (ART) and social awareness; transmission occurs during substance use. Cocaine usage independently affects brain activity and may result in reduced ART adherence. This study evaluates brain glucose metabol...

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Autores principales: Mamidi, Ramya S., Ayubcha, Cyrus, Rigney, Grant, Kirschner, Jason, Gerke, Oke, Werner, Thomas J., Tebas, Pablo, Alavi, Abass, Revheim, Mona-Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090338/
https://www.ncbi.nlm.nih.gov/pubmed/36727840
http://dx.doi.org/10.1097/QAD.0000000000003485
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author Mamidi, Ramya S.
Ayubcha, Cyrus
Rigney, Grant
Kirschner, Jason
Gerke, Oke
Werner, Thomas J.
Tebas, Pablo
Alavi, Abass
Revheim, Mona-Elisabeth
author_facet Mamidi, Ramya S.
Ayubcha, Cyrus
Rigney, Grant
Kirschner, Jason
Gerke, Oke
Werner, Thomas J.
Tebas, Pablo
Alavi, Abass
Revheim, Mona-Elisabeth
author_sort Mamidi, Ramya S.
collection PubMed
description HIV affects 36 million people globally with prevalence decreasing due to antiretroviral therapy (ART) and social awareness; transmission occurs during substance use. Cocaine usage independently affects brain activity and may result in reduced ART adherence. This study evaluates brain glucose metabolism measured by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in cocaine users with HIV infection. DESIGN: Sixty-three participants were categorized into groups: 36 HIV infected (HIV+) and 27 non-HIV infected (HIV−) individuals. Each group was further split into cocaine users (CO+) and non-cocaine users (CO−). Of the HIV+, half were cocaine users and half were not. Of the HIV−, 14 were cocaine users and 13 were not. (18)F-FDG-PET and low dose CT scans were performed on all participants. METHODS: Brain glucose metabolism was evaluated by (18)F-FDG uptake in the whole brain, cortex, basal ganglia, and cerebellum 120 min after injection. ROVER software was used for image analysis and regions of interest masks were applied via an adaptive threshold system. ANOVA tests and t-tests were performed to assess the respective differences between the four groups. RESULTS: Generally, the HIV+/CO+ group (group A) displayed the lowest levels of uptake whereas the HIV−/CO− group (group D) showed the highest; the HIV+/CO− and HIV−/CO+ groups (groups B and C) showed intermediate levels of activity across the whole brain, cortex, basal ganglia, and cerebellum. CONCLUSION: HIV infection and cocaine usage were independently associated with a decrease in brain glucose uptake as measured by (18)F-FDG PET/CT. When combined, positive HIV status and cocaine patients showed the most decreased (18)F-FDG uptake.
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spelling pubmed-100903382023-04-13 A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection Mamidi, Ramya S. Ayubcha, Cyrus Rigney, Grant Kirschner, Jason Gerke, Oke Werner, Thomas J. Tebas, Pablo Alavi, Abass Revheim, Mona-Elisabeth AIDS Clinical Science HIV affects 36 million people globally with prevalence decreasing due to antiretroviral therapy (ART) and social awareness; transmission occurs during substance use. Cocaine usage independently affects brain activity and may result in reduced ART adherence. This study evaluates brain glucose metabolism measured by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in cocaine users with HIV infection. DESIGN: Sixty-three participants were categorized into groups: 36 HIV infected (HIV+) and 27 non-HIV infected (HIV−) individuals. Each group was further split into cocaine users (CO+) and non-cocaine users (CO−). Of the HIV+, half were cocaine users and half were not. Of the HIV−, 14 were cocaine users and 13 were not. (18)F-FDG-PET and low dose CT scans were performed on all participants. METHODS: Brain glucose metabolism was evaluated by (18)F-FDG uptake in the whole brain, cortex, basal ganglia, and cerebellum 120 min after injection. ROVER software was used for image analysis and regions of interest masks were applied via an adaptive threshold system. ANOVA tests and t-tests were performed to assess the respective differences between the four groups. RESULTS: Generally, the HIV+/CO+ group (group A) displayed the lowest levels of uptake whereas the HIV−/CO− group (group D) showed the highest; the HIV+/CO− and HIV−/CO+ groups (groups B and C) showed intermediate levels of activity across the whole brain, cortex, basal ganglia, and cerebellum. CONCLUSION: HIV infection and cocaine usage were independently associated with a decrease in brain glucose uptake as measured by (18)F-FDG PET/CT. When combined, positive HIV status and cocaine patients showed the most decreased (18)F-FDG uptake. Lippincott Williams & Wilkins 2023-05-01 2023-01-19 /pmc/articles/PMC10090338/ /pubmed/36727840 http://dx.doi.org/10.1097/QAD.0000000000003485 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Clinical Science
Mamidi, Ramya S.
Ayubcha, Cyrus
Rigney, Grant
Kirschner, Jason
Gerke, Oke
Werner, Thomas J.
Tebas, Pablo
Alavi, Abass
Revheim, Mona-Elisabeth
A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection
title A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection
title_full A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection
title_fullStr A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection
title_full_unstemmed A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection
title_short A prospective (18)F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection
title_sort prospective (18)f-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and hiv infection
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090338/
https://www.ncbi.nlm.nih.gov/pubmed/36727840
http://dx.doi.org/10.1097/QAD.0000000000003485
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