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The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study

BACKGROUND: Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms. The latter mainly include affective, sleep, and cognitive deficits. Non-demented PD patients often demonstrate impairments in several executive domains following neuropsycholog...

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Autores principales: Ilardi, Ciro Rosario, di Maio, Girolamo, Villano, Ines, Messina, Giovanni, Monda, Vincenzo, Messina, Antonietta, Porro, Chiara, Panaro, Maria Antonietta, Gamboz, Nadia, Iavarone, Alessandro, La Marra, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090354/
https://www.ncbi.nlm.nih.gov/pubmed/37063521
http://dx.doi.org/10.3389/fpsyg.2023.1121251
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author Ilardi, Ciro Rosario
di Maio, Girolamo
Villano, Ines
Messina, Giovanni
Monda, Vincenzo
Messina, Antonietta
Porro, Chiara
Panaro, Maria Antonietta
Gamboz, Nadia
Iavarone, Alessandro
La Marra, Marco
author_facet Ilardi, Ciro Rosario
di Maio, Girolamo
Villano, Ines
Messina, Giovanni
Monda, Vincenzo
Messina, Antonietta
Porro, Chiara
Panaro, Maria Antonietta
Gamboz, Nadia
Iavarone, Alessandro
La Marra, Marco
author_sort Ilardi, Ciro Rosario
collection PubMed
description BACKGROUND: Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms. The latter mainly include affective, sleep, and cognitive deficits. Non-demented PD patients often demonstrate impairments in several executive domains following neuropsychological evaluation. The current pilot study aims at assessing the discriminatory power of the Frontal Assessment Battery-15 (FAB15) in differentiating (i) non-demented PD patients and healthy controls and (ii) PD patients with more and less pronounced motor symptoms. METHODS: Thirty-nine non-demented early-stage PD patients in the “on” dopamine state (26 females, mean age = 64.51 years, SD = 6.47, mean disease duration = 5.49 years, SD = 2.28) and 39 healthy participants (24 females, mean age = 62.60 years, SD = 5.51) were included in the study. All participants completed the FAB15. Motor symptoms of PD patients were quantified via the Unified Parkinson’s Disease Rating Scale-Part III (UPDRS-Part III) and Hoehn and Yahr staging scale (H&Y). RESULTS: The FAB15 score, adjusted according to normative data for sex, age, and education, proved to be sufficiently able to discriminate PD patients from healthy controls (AUC = 0.69 [95% CI 0.60–0.75], SE = 0.06, p = 0.04, optimal cutoff = 11.29). Conversely, the battery lacked sufficient discriminative capability to differentiate PD patients based on the severity of motor symptoms. CONCLUSION: The FAB15 may be a valid tool for distinguishing PD patients from healthy controls. However, it might be less sensitive in identifying clinical phenotypes characterized by visuospatial impairments resulting from posteroparietal and/or temporal dysfunctions. In line with previous evidence, the battery demonstrated to be not expendable in the clinical practice for monitoring the severity of PD-related motor symptoms.
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spelling pubmed-100903542023-04-13 The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study Ilardi, Ciro Rosario di Maio, Girolamo Villano, Ines Messina, Giovanni Monda, Vincenzo Messina, Antonietta Porro, Chiara Panaro, Maria Antonietta Gamboz, Nadia Iavarone, Alessandro La Marra, Marco Front Psychol Psychology BACKGROUND: Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms. The latter mainly include affective, sleep, and cognitive deficits. Non-demented PD patients often demonstrate impairments in several executive domains following neuropsychological evaluation. The current pilot study aims at assessing the discriminatory power of the Frontal Assessment Battery-15 (FAB15) in differentiating (i) non-demented PD patients and healthy controls and (ii) PD patients with more and less pronounced motor symptoms. METHODS: Thirty-nine non-demented early-stage PD patients in the “on” dopamine state (26 females, mean age = 64.51 years, SD = 6.47, mean disease duration = 5.49 years, SD = 2.28) and 39 healthy participants (24 females, mean age = 62.60 years, SD = 5.51) were included in the study. All participants completed the FAB15. Motor symptoms of PD patients were quantified via the Unified Parkinson’s Disease Rating Scale-Part III (UPDRS-Part III) and Hoehn and Yahr staging scale (H&Y). RESULTS: The FAB15 score, adjusted according to normative data for sex, age, and education, proved to be sufficiently able to discriminate PD patients from healthy controls (AUC = 0.69 [95% CI 0.60–0.75], SE = 0.06, p = 0.04, optimal cutoff = 11.29). Conversely, the battery lacked sufficient discriminative capability to differentiate PD patients based on the severity of motor symptoms. CONCLUSION: The FAB15 may be a valid tool for distinguishing PD patients from healthy controls. However, it might be less sensitive in identifying clinical phenotypes characterized by visuospatial impairments resulting from posteroparietal and/or temporal dysfunctions. In line with previous evidence, the battery demonstrated to be not expendable in the clinical practice for monitoring the severity of PD-related motor symptoms. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090354/ /pubmed/37063521 http://dx.doi.org/10.3389/fpsyg.2023.1121251 Text en Copyright © 2023 Ilardi, di Maio, Villano, Messina, Monda, Messina, Porro, Panaro, Gamboz, Iavarone and La Marra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Ilardi, Ciro Rosario
di Maio, Girolamo
Villano, Ines
Messina, Giovanni
Monda, Vincenzo
Messina, Antonietta
Porro, Chiara
Panaro, Maria Antonietta
Gamboz, Nadia
Iavarone, Alessandro
La Marra, Marco
The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study
title The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study
title_full The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study
title_fullStr The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study
title_full_unstemmed The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study
title_short The assessment of executive functions to test the integrity of the nigrostriatal network: A pilot study
title_sort assessment of executive functions to test the integrity of the nigrostriatal network: a pilot study
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090354/
https://www.ncbi.nlm.nih.gov/pubmed/37063521
http://dx.doi.org/10.3389/fpsyg.2023.1121251
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