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Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review

While it is common for pregnant women to take anesthesia during surgery, the effects of prenatal anesthesia exposure (PAE) on the long-term neurodevelopment of the offspring remain to be clarified. Preclinical animal research has shown that in utero anesthetic exposure causes neurotoxicity in newbor...

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Autores principales: Zhou, Nannan, Liang, Shuang, Yue, Xinying, Zou, Wangyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090376/
https://www.ncbi.nlm.nih.gov/pubmed/37064201
http://dx.doi.org/10.3389/fneur.2023.1146569
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author Zhou, Nannan
Liang, Shuang
Yue, Xinying
Zou, Wangyuan
author_facet Zhou, Nannan
Liang, Shuang
Yue, Xinying
Zou, Wangyuan
author_sort Zhou, Nannan
collection PubMed
description While it is common for pregnant women to take anesthesia during surgery, the effects of prenatal anesthesia exposure (PAE) on the long-term neurodevelopment of the offspring remain to be clarified. Preclinical animal research has shown that in utero anesthetic exposure causes neurotoxicity in newborns, which is mainly characterized by histomorphological changes and altered learning and memory abilities. Regional birth cohort studies that are based on databases are currently the most convenient and popular types of clinical studies. Specialized questionnaires and scales are usually employed in these studies for the screening and diagnosis of neurodevelopmental disorders in the offspring. The time intervals between the intrauterine exposure and the onset of developmental outcomes often vary over several years and accommodate a large number of confounding factors, which have an even greater impact on the neurodevelopment of the offspring than prenatal anesthesia itself. This narrative review summarized the progress in prenatal anesthetic exposure and neurodevelopmental outcomes in the offspring from animal experimental research and clinical studies and provided a brief introduction to assess the neurodevelopment in children and potential confounding factors.
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spelling pubmed-100903762023-04-13 Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review Zhou, Nannan Liang, Shuang Yue, Xinying Zou, Wangyuan Front Neurol Neurology While it is common for pregnant women to take anesthesia during surgery, the effects of prenatal anesthesia exposure (PAE) on the long-term neurodevelopment of the offspring remain to be clarified. Preclinical animal research has shown that in utero anesthetic exposure causes neurotoxicity in newborns, which is mainly characterized by histomorphological changes and altered learning and memory abilities. Regional birth cohort studies that are based on databases are currently the most convenient and popular types of clinical studies. Specialized questionnaires and scales are usually employed in these studies for the screening and diagnosis of neurodevelopmental disorders in the offspring. The time intervals between the intrauterine exposure and the onset of developmental outcomes often vary over several years and accommodate a large number of confounding factors, which have an even greater impact on the neurodevelopment of the offspring than prenatal anesthesia itself. This narrative review summarized the progress in prenatal anesthetic exposure and neurodevelopmental outcomes in the offspring from animal experimental research and clinical studies and provided a brief introduction to assess the neurodevelopment in children and potential confounding factors. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090376/ /pubmed/37064201 http://dx.doi.org/10.3389/fneur.2023.1146569 Text en Copyright © 2023 Zhou, Liang, Yue and Zou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhou, Nannan
Liang, Shuang
Yue, Xinying
Zou, Wangyuan
Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
title Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
title_full Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
title_fullStr Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
title_full_unstemmed Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
title_short Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
title_sort prenatal anesthetic exposure and offspring neurodevelopmental outcomes—a narrative review
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090376/
https://www.ncbi.nlm.nih.gov/pubmed/37064201
http://dx.doi.org/10.3389/fneur.2023.1146569
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