The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal...

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Autores principales: Dong, Changchao, Tan, Gang, Zhang, Guangyan, Lin, Wei, Wang, Guanglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090379/
https://www.ncbi.nlm.nih.gov/pubmed/37064239
http://dx.doi.org/10.3389/fbioe.2023.1133995
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author Dong, Changchao
Tan, Gang
Zhang, Guangyan
Lin, Wei
Wang, Guanglin
author_facet Dong, Changchao
Tan, Gang
Zhang, Guangyan
Lin, Wei
Wang, Guanglin
author_sort Dong, Changchao
collection PubMed
description The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.
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spelling pubmed-100903792023-04-13 The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review Dong, Changchao Tan, Gang Zhang, Guangyan Lin, Wei Wang, Guanglin Front Bioeng Biotechnol Bioengineering and Biotechnology The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090379/ /pubmed/37064239 http://dx.doi.org/10.3389/fbioe.2023.1133995 Text en Copyright © 2023 Dong, Tan, Zhang, Lin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Dong, Changchao
Tan, Gang
Zhang, Guangyan
Lin, Wei
Wang, Guanglin
The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
title The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
title_full The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
title_fullStr The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
title_full_unstemmed The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
title_short The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review
title_sort function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: a review
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090379/
https://www.ncbi.nlm.nih.gov/pubmed/37064239
http://dx.doi.org/10.3389/fbioe.2023.1133995
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