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Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications

Ehlers–Danlos syndromes (EDS) represent a group of rare inherited disorders that affect connective tissues. There are 13 types of disease, most of them affecting joints or skin; symptoms usually include loose joints, joint pain, stretchy velvety skin, abnormal scar formation. However, the most serio...

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Autores principales: Cherecheanu, Matei Popa, Romanitan, Mihaela Oana, Pirvulescu, Ruxandra, Iancu, Raluca, Garhöfer, Gerhard, Iancu, George, Cherecheanu, Alina Popa, Zemba, Mihail, Vasile, Victor, Simonov, Andrei, Branisteanu, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090385/
https://www.ncbi.nlm.nih.gov/pubmed/37064021
http://dx.doi.org/10.3389/fmed.2023.1089652
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author Cherecheanu, Matei Popa
Romanitan, Mihaela Oana
Pirvulescu, Ruxandra
Iancu, Raluca
Garhöfer, Gerhard
Iancu, George
Cherecheanu, Alina Popa
Zemba, Mihail
Vasile, Victor
Simonov, Andrei
Branisteanu, Daniel
author_facet Cherecheanu, Matei Popa
Romanitan, Mihaela Oana
Pirvulescu, Ruxandra
Iancu, Raluca
Garhöfer, Gerhard
Iancu, George
Cherecheanu, Alina Popa
Zemba, Mihail
Vasile, Victor
Simonov, Andrei
Branisteanu, Daniel
author_sort Cherecheanu, Matei Popa
collection PubMed
description Ehlers–Danlos syndromes (EDS) represent a group of rare inherited disorders that affect connective tissues. There are 13 types of disease, most of them affecting joints or skin; symptoms usually include loose joints, joint pain, stretchy velvety skin, abnormal scar formation. However, the most serious type of disease is vascular EDS (vEDS), or EDS type 4 because patients may suffer vessels dissections or internal organs lesions, followed by bleeding, which endangers patient’s life, but also thromboembolic events. We present two clinical cases of vEDS managed in our clinic in 1 year distance. In both cases, patients were active young persons (in their thirties, and respectively, twenties), both with multiple non-traumatic vascular dissections, and severe ocular complications: arterio-venous fistula with massive exophthalmia, and central retinal artery occlusion, respectively. Both cases were challenging since the life of the patients were threatened by their condition. However, in both cases, prompt treatment and finding the right trigger of the ocular pathology and vascular injuries helped doctors to provide proper and prompt medical care, in order to prevent future similar events to happen and to preserve a good quality of life for these patients.
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spelling pubmed-100903852023-04-13 Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications Cherecheanu, Matei Popa Romanitan, Mihaela Oana Pirvulescu, Ruxandra Iancu, Raluca Garhöfer, Gerhard Iancu, George Cherecheanu, Alina Popa Zemba, Mihail Vasile, Victor Simonov, Andrei Branisteanu, Daniel Front Med (Lausanne) Medicine Ehlers–Danlos syndromes (EDS) represent a group of rare inherited disorders that affect connective tissues. There are 13 types of disease, most of them affecting joints or skin; symptoms usually include loose joints, joint pain, stretchy velvety skin, abnormal scar formation. However, the most serious type of disease is vascular EDS (vEDS), or EDS type 4 because patients may suffer vessels dissections or internal organs lesions, followed by bleeding, which endangers patient’s life, but also thromboembolic events. We present two clinical cases of vEDS managed in our clinic in 1 year distance. In both cases, patients were active young persons (in their thirties, and respectively, twenties), both with multiple non-traumatic vascular dissections, and severe ocular complications: arterio-venous fistula with massive exophthalmia, and central retinal artery occlusion, respectively. Both cases were challenging since the life of the patients were threatened by their condition. However, in both cases, prompt treatment and finding the right trigger of the ocular pathology and vascular injuries helped doctors to provide proper and prompt medical care, in order to prevent future similar events to happen and to preserve a good quality of life for these patients. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090385/ /pubmed/37064021 http://dx.doi.org/10.3389/fmed.2023.1089652 Text en Copyright © 2023 Cherecheanu, Romanitan, Pirvulescu, Iancu, Garhöfer, Iancu, Cherecheanu, Zemba, Vasile, Simonov and Branisteanu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Cherecheanu, Matei Popa
Romanitan, Mihaela Oana
Pirvulescu, Ruxandra
Iancu, Raluca
Garhöfer, Gerhard
Iancu, George
Cherecheanu, Alina Popa
Zemba, Mihail
Vasile, Victor
Simonov, Andrei
Branisteanu, Daniel
Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
title Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
title_full Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
title_fullStr Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
title_full_unstemmed Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
title_short Uncommon association between vascular Ehlers–Danlos syndrome and ocular complications
title_sort uncommon association between vascular ehlers–danlos syndrome and ocular complications
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090385/
https://www.ncbi.nlm.nih.gov/pubmed/37064021
http://dx.doi.org/10.3389/fmed.2023.1089652
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