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The regulatory role of microRNAs in common eye diseases: A brief review
MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090401/ https://www.ncbi.nlm.nih.gov/pubmed/37065488 http://dx.doi.org/10.3389/fgene.2023.1152110 |
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author | Benavides-Aguilar, Javier A. Morales-Rodríguez, Jonathan I. Ambriz-González, Héctor Ruiz-Manriquez, Luis M. Banerjee, Antara Pathak, Surajit Duttaroy, Asim K. Paul, Sujay |
author_facet | Benavides-Aguilar, Javier A. Morales-Rodríguez, Jonathan I. Ambriz-González, Héctor Ruiz-Manriquez, Luis M. Banerjee, Antara Pathak, Surajit Duttaroy, Asim K. Paul, Sujay |
author_sort | Benavides-Aguilar, Javier A. |
collection | PubMed |
description | MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management. |
format | Online Article Text |
id | pubmed-10090401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100904012023-04-13 The regulatory role of microRNAs in common eye diseases: A brief review Benavides-Aguilar, Javier A. Morales-Rodríguez, Jonathan I. Ambriz-González, Héctor Ruiz-Manriquez, Luis M. Banerjee, Antara Pathak, Surajit Duttaroy, Asim K. Paul, Sujay Front Genet Genetics MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090401/ /pubmed/37065488 http://dx.doi.org/10.3389/fgene.2023.1152110 Text en Copyright © 2023 Benavides-Aguilar, Morales-Rodríguez, Ambriz-González, Ruiz-Manriquez, Banerjee, Pathak, Duttaroy and Paul. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Benavides-Aguilar, Javier A. Morales-Rodríguez, Jonathan I. Ambriz-González, Héctor Ruiz-Manriquez, Luis M. Banerjee, Antara Pathak, Surajit Duttaroy, Asim K. Paul, Sujay The regulatory role of microRNAs in common eye diseases: A brief review |
title | The regulatory role of microRNAs in common eye diseases: A brief review |
title_full | The regulatory role of microRNAs in common eye diseases: A brief review |
title_fullStr | The regulatory role of microRNAs in common eye diseases: A brief review |
title_full_unstemmed | The regulatory role of microRNAs in common eye diseases: A brief review |
title_short | The regulatory role of microRNAs in common eye diseases: A brief review |
title_sort | regulatory role of micrornas in common eye diseases: a brief review |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090401/ https://www.ncbi.nlm.nih.gov/pubmed/37065488 http://dx.doi.org/10.3389/fgene.2023.1152110 |
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