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The regulatory role of microRNAs in common eye diseases: A brief review

MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression...

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Autores principales: Benavides-Aguilar, Javier A., Morales-Rodríguez, Jonathan I., Ambriz-González, Héctor, Ruiz-Manriquez, Luis M., Banerjee, Antara, Pathak, Surajit, Duttaroy, Asim K., Paul, Sujay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090401/
https://www.ncbi.nlm.nih.gov/pubmed/37065488
http://dx.doi.org/10.3389/fgene.2023.1152110
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author Benavides-Aguilar, Javier A.
Morales-Rodríguez, Jonathan I.
Ambriz-González, Héctor
Ruiz-Manriquez, Luis M.
Banerjee, Antara
Pathak, Surajit
Duttaroy, Asim K.
Paul, Sujay
author_facet Benavides-Aguilar, Javier A.
Morales-Rodríguez, Jonathan I.
Ambriz-González, Héctor
Ruiz-Manriquez, Luis M.
Banerjee, Antara
Pathak, Surajit
Duttaroy, Asim K.
Paul, Sujay
author_sort Benavides-Aguilar, Javier A.
collection PubMed
description MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management.
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spelling pubmed-100904012023-04-13 The regulatory role of microRNAs in common eye diseases: A brief review Benavides-Aguilar, Javier A. Morales-Rodríguez, Jonathan I. Ambriz-González, Héctor Ruiz-Manriquez, Luis M. Banerjee, Antara Pathak, Surajit Duttaroy, Asim K. Paul, Sujay Front Genet Genetics MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090401/ /pubmed/37065488 http://dx.doi.org/10.3389/fgene.2023.1152110 Text en Copyright © 2023 Benavides-Aguilar, Morales-Rodríguez, Ambriz-González, Ruiz-Manriquez, Banerjee, Pathak, Duttaroy and Paul. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Benavides-Aguilar, Javier A.
Morales-Rodríguez, Jonathan I.
Ambriz-González, Héctor
Ruiz-Manriquez, Luis M.
Banerjee, Antara
Pathak, Surajit
Duttaroy, Asim K.
Paul, Sujay
The regulatory role of microRNAs in common eye diseases: A brief review
title The regulatory role of microRNAs in common eye diseases: A brief review
title_full The regulatory role of microRNAs in common eye diseases: A brief review
title_fullStr The regulatory role of microRNAs in common eye diseases: A brief review
title_full_unstemmed The regulatory role of microRNAs in common eye diseases: A brief review
title_short The regulatory role of microRNAs in common eye diseases: A brief review
title_sort regulatory role of micrornas in common eye diseases: a brief review
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090401/
https://www.ncbi.nlm.nih.gov/pubmed/37065488
http://dx.doi.org/10.3389/fgene.2023.1152110
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