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Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease
Interstitial lung disease (ILD) is one of the most serious lung complications of connective tissue disease (CTD). The application of proteomics in the past decade has revealed that various proteins are involved in the pathogenesis of each subtype of CTD-ILD through different pathways, providing nove...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090492/ https://www.ncbi.nlm.nih.gov/pubmed/37063894 http://dx.doi.org/10.3389/fimmu.2023.1146904 |
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author | Wu, Yinlan Li, Yanhong Luo, Yubin Zhou, Yu Liang, Xiuping Cheng, Lu Wu, Tong Wen, Ji Tan, Chunyu Liu, Yi |
author_facet | Wu, Yinlan Li, Yanhong Luo, Yubin Zhou, Yu Liang, Xiuping Cheng, Lu Wu, Tong Wen, Ji Tan, Chunyu Liu, Yi |
author_sort | Wu, Yinlan |
collection | PubMed |
description | Interstitial lung disease (ILD) is one of the most serious lung complications of connective tissue disease (CTD). The application of proteomics in the past decade has revealed that various proteins are involved in the pathogenesis of each subtype of CTD-ILD through different pathways, providing novel ideas to study pathological mechanisms and clinical biomarkers. On this basis, a multidimensional diagnosis or prediction model is established. This paper reviews the results of proteomic detection of different subtypes of CTD-ILD and discusses the role of some differentially expressed proteins in the development of pulmonary fibrosis and their potential clinical applications. |
format | Online Article Text |
id | pubmed-10090492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100904922023-04-13 Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease Wu, Yinlan Li, Yanhong Luo, Yubin Zhou, Yu Liang, Xiuping Cheng, Lu Wu, Tong Wen, Ji Tan, Chunyu Liu, Yi Front Immunol Immunology Interstitial lung disease (ILD) is one of the most serious lung complications of connective tissue disease (CTD). The application of proteomics in the past decade has revealed that various proteins are involved in the pathogenesis of each subtype of CTD-ILD through different pathways, providing novel ideas to study pathological mechanisms and clinical biomarkers. On this basis, a multidimensional diagnosis or prediction model is established. This paper reviews the results of proteomic detection of different subtypes of CTD-ILD and discusses the role of some differentially expressed proteins in the development of pulmonary fibrosis and their potential clinical applications. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090492/ /pubmed/37063894 http://dx.doi.org/10.3389/fimmu.2023.1146904 Text en Copyright © 2023 Wu, Li, Luo, Zhou, Liang, Cheng, Wu, Wen, Tan and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Yinlan Li, Yanhong Luo, Yubin Zhou, Yu Liang, Xiuping Cheng, Lu Wu, Tong Wen, Ji Tan, Chunyu Liu, Yi Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
title | Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
title_full | Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
title_fullStr | Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
title_full_unstemmed | Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
title_short | Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
title_sort | proteomics: potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090492/ https://www.ncbi.nlm.nih.gov/pubmed/37063894 http://dx.doi.org/10.3389/fimmu.2023.1146904 |
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