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Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis

Over the last few decades, the incidence of multiple sclerosis has increased as society’s dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the “Western diet.” Environmental factors, such as diet, could play a role i...

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Autores principales: Hoffman, Kristina, Doyle, William J., Schumacher, Sean M., Ochoa-Repáraz, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090556/
https://www.ncbi.nlm.nih.gov/pubmed/37063324
http://dx.doi.org/10.3389/fnut.2023.1146748
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author Hoffman, Kristina
Doyle, William J.
Schumacher, Sean M.
Ochoa-Repáraz, Javier
author_facet Hoffman, Kristina
Doyle, William J.
Schumacher, Sean M.
Ochoa-Repáraz, Javier
author_sort Hoffman, Kristina
collection PubMed
description Over the last few decades, the incidence of multiple sclerosis has increased as society’s dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the “Western diet.” Environmental factors, such as diet, could play a role in the pathogenesis of multiple sclerosis due to gut microbiota alterations, gut barrier leakage, and subsequent intestinal inflammation that could lead to exacerbated neuroinflammation. This mini-review explores the gut microbiome alterations of various dietary strategies that improve upon the “Western diet” as promising alternatives and targets to current multiple sclerosis treatments. We also provide evidence that gut microbiome modulation through diet can improve or exacerbate clinical symptoms of multiple sclerosis, highlighting the importance of including gut microbiome analyses in future studies of diet and disease.
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spelling pubmed-100905562023-04-13 Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis Hoffman, Kristina Doyle, William J. Schumacher, Sean M. Ochoa-Repáraz, Javier Front Nutr Nutrition Over the last few decades, the incidence of multiple sclerosis has increased as society’s dietary habits have switched from a whole foods approach to a high fat, high salt, low dietary fiber, and processed food diet, termed the “Western diet.” Environmental factors, such as diet, could play a role in the pathogenesis of multiple sclerosis due to gut microbiota alterations, gut barrier leakage, and subsequent intestinal inflammation that could lead to exacerbated neuroinflammation. This mini-review explores the gut microbiome alterations of various dietary strategies that improve upon the “Western diet” as promising alternatives and targets to current multiple sclerosis treatments. We also provide evidence that gut microbiome modulation through diet can improve or exacerbate clinical symptoms of multiple sclerosis, highlighting the importance of including gut microbiome analyses in future studies of diet and disease. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090556/ /pubmed/37063324 http://dx.doi.org/10.3389/fnut.2023.1146748 Text en Copyright © 2023 Hoffman, Doyle, Schumacher and Ochoa-Repáraz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Hoffman, Kristina
Doyle, William J.
Schumacher, Sean M.
Ochoa-Repáraz, Javier
Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
title Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
title_full Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
title_fullStr Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
title_full_unstemmed Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
title_short Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis
title_sort gut microbiome-modulated dietary strategies in eae and multiple sclerosis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090556/
https://www.ncbi.nlm.nih.gov/pubmed/37063324
http://dx.doi.org/10.3389/fnut.2023.1146748
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