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Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs
Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal immunoglobulin preparations such as IVIG and SCIG represe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090664/ https://www.ncbi.nlm.nih.gov/pubmed/37063852 http://dx.doi.org/10.3389/fimmu.2023.1166821 |
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author | von Gunten, Stephan Schneider, Christoph Imamovic, Lejla Gorochov, Guy |
author_facet | von Gunten, Stephan Schneider, Christoph Imamovic, Lejla Gorochov, Guy |
author_sort | von Gunten, Stephan |
collection | PubMed |
description | Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal immunoglobulin preparations such as IVIG and SCIG represent the IgG repertoire of the donor population and will likely remain the cornerstone of antibody replacement therapy in immunodeficiencies. However, novel evidence suggests that pooled IgA might promote orthobiotic microbial colonization in gut dysbiosis linked to mucosal IgA immunodeficiency. Plasma-derived polyclonal IgG and IgA exhibit immunoregulatory effects by a diversity of different mechanisms, which have inspired the development of novel drugs. Here we highlight recent insights into IgG and IgA repertoires and discuss potential implications for polyclonal immunoglobulin therapy and inspired drugs. |
format | Online Article Text |
id | pubmed-10090664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100906642023-04-13 Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs von Gunten, Stephan Schneider, Christoph Imamovic, Lejla Gorochov, Guy Front Immunol Immunology Significant progress has been made in the elucidation of human antibody repertoires. Furthermore, non-canonical functions of antibodies have been identified that reach beyond classical functions linked to protection from pathogens. Polyclonal immunoglobulin preparations such as IVIG and SCIG represent the IgG repertoire of the donor population and will likely remain the cornerstone of antibody replacement therapy in immunodeficiencies. However, novel evidence suggests that pooled IgA might promote orthobiotic microbial colonization in gut dysbiosis linked to mucosal IgA immunodeficiency. Plasma-derived polyclonal IgG and IgA exhibit immunoregulatory effects by a diversity of different mechanisms, which have inspired the development of novel drugs. Here we highlight recent insights into IgG and IgA repertoires and discuss potential implications for polyclonal immunoglobulin therapy and inspired drugs. Frontiers Media S.A. 2023-03-28 /pmc/articles/PMC10090664/ /pubmed/37063852 http://dx.doi.org/10.3389/fimmu.2023.1166821 Text en Copyright © 2023 von Gunten, Schneider, Imamovic and Gorochov https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology von Gunten, Stephan Schneider, Christoph Imamovic, Lejla Gorochov, Guy Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs |
title | Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs |
title_full | Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs |
title_fullStr | Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs |
title_full_unstemmed | Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs |
title_short | Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs |
title_sort | antibody diversity in ivig: therapeutic opportunities for novel immunotherapeutic drugs |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090664/ https://www.ncbi.nlm.nih.gov/pubmed/37063852 http://dx.doi.org/10.3389/fimmu.2023.1166821 |
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