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Advances in the study of myeloid-derived suppressor cells in infectious lung diseases

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of the immune response of the body to pathogens, especially in inflammatory response and pathogenesis during anti-infection. P...

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Autores principales: Zhang, Meng-Nan, Yuan, Yu-Lai, Ao, Su-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090681/
https://www.ncbi.nlm.nih.gov/pubmed/37063919
http://dx.doi.org/10.3389/fimmu.2023.1125737
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author Zhang, Meng-Nan
Yuan, Yu-Lai
Ao, Su-Hua
author_facet Zhang, Meng-Nan
Yuan, Yu-Lai
Ao, Su-Hua
author_sort Zhang, Meng-Nan
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of the immune response of the body to pathogens, especially in inflammatory response and pathogenesis during anti-infection. Pathogens such as bacteria and viruses use MDSCs as their infectious targets, and even some pathogens may exploit the inhibitory activity of MDSCs to enhance pathogen persistence and chronic infection of the host. Recent researches have revealed the pathogenic significance of MDSCs in pathogens such as bacteria and viruses, despite the fact that the majority of studies on MDSCs have focused on tumor immune evasion. With the increased prevalence of viral respiratory infections, the resurgence of classical tuberculosis, and the advent of medication resistance in common bacterial pneumonia, research on MDSCs in these illnesses is intensifying. The purpose of this work is to provide new avenues for treatment approaches to pulmonary infectious disorders by outlining the mechanism of action of MDSCs as a biomarker and therapeutic target in pulmonary infectious diseases.
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spelling pubmed-100906812023-04-13 Advances in the study of myeloid-derived suppressor cells in infectious lung diseases Zhang, Meng-Nan Yuan, Yu-Lai Ao, Su-Hua Front Immunol Immunology Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of the immune response of the body to pathogens, especially in inflammatory response and pathogenesis during anti-infection. Pathogens such as bacteria and viruses use MDSCs as their infectious targets, and even some pathogens may exploit the inhibitory activity of MDSCs to enhance pathogen persistence and chronic infection of the host. Recent researches have revealed the pathogenic significance of MDSCs in pathogens such as bacteria and viruses, despite the fact that the majority of studies on MDSCs have focused on tumor immune evasion. With the increased prevalence of viral respiratory infections, the resurgence of classical tuberculosis, and the advent of medication resistance in common bacterial pneumonia, research on MDSCs in these illnesses is intensifying. The purpose of this work is to provide new avenues for treatment approaches to pulmonary infectious disorders by outlining the mechanism of action of MDSCs as a biomarker and therapeutic target in pulmonary infectious diseases. Frontiers Media S.A. 2023-03-29 /pmc/articles/PMC10090681/ /pubmed/37063919 http://dx.doi.org/10.3389/fimmu.2023.1125737 Text en Copyright © 2023 Zhang, Yuan and Ao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Meng-Nan
Yuan, Yu-Lai
Ao, Su-Hua
Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
title Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
title_full Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
title_fullStr Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
title_full_unstemmed Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
title_short Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
title_sort advances in the study of myeloid-derived suppressor cells in infectious lung diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090681/
https://www.ncbi.nlm.nih.gov/pubmed/37063919
http://dx.doi.org/10.3389/fimmu.2023.1125737
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