A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, we identify the host defense peptide mimetic, brilacidin (BRI) as a synergizer with caspofungin (CAS) agains...

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Detalles Bibliográficos
Autores principales: dos Reis, Thaila Fernanda, de Castro, Patrícia Alves, Bastos, Rafael Wesley, Pinzan, Camila Figueiredo, Souza, Pedro F. N., Ackloo, Suzanne, Hossain, Mohammad Anwar, Drewry, David Harold, Alkhazraji, Sondus, Ibrahim, Ashraf S., Jo, Hyunil, Lightfoot, Jorge D., Adams, Emily M., Fuller, Kevin K., deGrado, William F., Goldman, Gustavo H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090755/
https://www.ncbi.nlm.nih.gov/pubmed/37045836
http://dx.doi.org/10.1038/s41467-023-37573-y

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