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Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels

The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas b...

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Autores principales: AlGhamdi, Shareefa A., Al-Abbasi, Fahad A., Alghamdi, Amira M., Omer, Asma B., Afzal, Obaid, Altamimi, Abdulmalik S. A., Alamri, Abdulaziz, Alzarea, Sami I., Almalki, Waleed Hassan, Kazmi, Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090886/
https://www.ncbi.nlm.nih.gov/pubmed/37063992
http://dx.doi.org/10.1098/rsos.230013
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author AlGhamdi, Shareefa A.
Al-Abbasi, Fahad A.
Alghamdi, Amira M.
Omer, Asma B.
Afzal, Obaid
Altamimi, Abdulmalik S. A.
Alamri, Abdulaziz
Alzarea, Sami I.
Almalki, Waleed Hassan
Kazmi, Imran
author_facet AlGhamdi, Shareefa A.
Al-Abbasi, Fahad A.
Alghamdi, Amira M.
Omer, Asma B.
Afzal, Obaid
Altamimi, Abdulmalik S. A.
Alamri, Abdulaziz
Alzarea, Sami I.
Almalki, Waleed Hassan
Kazmi, Imran
author_sort AlGhamdi, Shareefa A.
collection PubMed
description The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg(−1)) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg(−1) day(−1) saline, and all other groups were administered SCOP (1 mg kg(−1) day(−1), i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain.
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spelling pubmed-100908862023-04-13 Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels AlGhamdi, Shareefa A. Al-Abbasi, Fahad A. Alghamdi, Amira M. Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Alamri, Abdulaziz Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran R Soc Open Sci Biochemistry, Cellular and Molecular Biology The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg(−1)) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg(−1) day(−1) saline, and all other groups were administered SCOP (1 mg kg(−1) day(−1), i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain. The Royal Society 2023-04-12 /pmc/articles/PMC10090886/ /pubmed/37063992 http://dx.doi.org/10.1098/rsos.230013 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Biochemistry, Cellular and Molecular Biology
AlGhamdi, Shareefa A.
Al-Abbasi, Fahad A.
Alghamdi, Amira M.
Omer, Asma B.
Afzal, Obaid
Altamimi, Abdulmalik S. A.
Alamri, Abdulaziz
Alzarea, Sami I.
Almalki, Waleed Hassan
Kazmi, Imran
Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
title Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
title_full Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
title_fullStr Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
title_full_unstemmed Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
title_short Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
title_sort barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
topic Biochemistry, Cellular and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090886/
https://www.ncbi.nlm.nih.gov/pubmed/37063992
http://dx.doi.org/10.1098/rsos.230013
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