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Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas b...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090886/ https://www.ncbi.nlm.nih.gov/pubmed/37063992 http://dx.doi.org/10.1098/rsos.230013 |
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author | AlGhamdi, Shareefa A. Al-Abbasi, Fahad A. Alghamdi, Amira M. Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Alamri, Abdulaziz Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran |
author_facet | AlGhamdi, Shareefa A. Al-Abbasi, Fahad A. Alghamdi, Amira M. Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Alamri, Abdulaziz Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran |
author_sort | AlGhamdi, Shareefa A. |
collection | PubMed |
description | The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg(−1)) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg(−1) day(−1) saline, and all other groups were administered SCOP (1 mg kg(−1) day(−1), i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain. |
format | Online Article Text |
id | pubmed-10090886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100908862023-04-13 Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels AlGhamdi, Shareefa A. Al-Abbasi, Fahad A. Alghamdi, Amira M. Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Alamri, Abdulaziz Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran R Soc Open Sci Biochemistry, Cellular and Molecular Biology The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg(−1)) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg(−1) day(−1) saline, and all other groups were administered SCOP (1 mg kg(−1) day(−1), i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain. The Royal Society 2023-04-12 /pmc/articles/PMC10090886/ /pubmed/37063992 http://dx.doi.org/10.1098/rsos.230013 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Biochemistry, Cellular and Molecular Biology AlGhamdi, Shareefa A. Al-Abbasi, Fahad A. Alghamdi, Amira M. Omer, Asma B. Afzal, Obaid Altamimi, Abdulmalik S. A. Alamri, Abdulaziz Alzarea, Sami I. Almalki, Waleed Hassan Kazmi, Imran Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
title | Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
title_full | Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
title_fullStr | Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
title_full_unstemmed | Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
title_short | Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
title_sort | barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels |
topic | Biochemistry, Cellular and Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090886/ https://www.ncbi.nlm.nih.gov/pubmed/37063992 http://dx.doi.org/10.1098/rsos.230013 |
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