Cargando…
Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis
AIM OF THE STUDY: We aimed to investigate the possible association between serum copeptin and complications of liver cirrhosis, including its potential role as a stress biomarker in spontaneous bacterial peritonitis (SBP). MATERIAL AND METHODS: This cross-sectional study included 89 cirrhotic asciti...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090990/ https://www.ncbi.nlm.nih.gov/pubmed/37064833 http://dx.doi.org/10.5114/ceh.2023.125970 |
_version_ | 1785023069983604736 |
---|---|
author | Abudeif, Ahmed Hashim, Marwa S. Ahmed, Nesma M. Ahmed, Ahmed Othman |
author_facet | Abudeif, Ahmed Hashim, Marwa S. Ahmed, Nesma M. Ahmed, Ahmed Othman |
author_sort | Abudeif, Ahmed |
collection | PubMed |
description | AIM OF THE STUDY: We aimed to investigate the possible association between serum copeptin and complications of liver cirrhosis, including its potential role as a stress biomarker in spontaneous bacterial peritonitis (SBP). MATERIAL AND METHODS: This cross-sectional study included 89 cirrhotic ascitic patients (37 with SBP and 52 without SBP) admitted to Sohag University Hospitals, Egypt, between June 2021 and February 2022. Serum copeptin was measured in all patients, and its association with SBP and other complications of liver cirrhosis was investigated. RESULTS: Serum copeptin was significantly elevated in patients with SBP compared to those without SBP (p = 0.032) and significantly correlated with ascitic fluid study parameters, systemic inflammatory markers, and liver, renal, and circulatory functions. Serum copeptin and C-reactive protein (CRP) were independent risk factors for the presence of SBP. Serum copeptin detects SBP at a cut-off value of 9 pmol/l, with sensitivity and specificity of 73% and 64%, respectively. Serum copeptin was significantly associated with hepatic encephalopathy, gastrointestinal bleeding, hepatorenal syndrome, and larger amounts of ascites. CONCLUSIONS: Serum copeptin is an independent risk factor for the presence of SBP and significantly increased in patients presented with major complications of liver cirrhosis, demonstrating its ability to reflect circulatory dysfunction and systemic inflammation. |
format | Online Article Text |
id | pubmed-10090990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-100909902023-04-13 Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis Abudeif, Ahmed Hashim, Marwa S. Ahmed, Nesma M. Ahmed, Ahmed Othman Clin Exp Hepatol Original Paper AIM OF THE STUDY: We aimed to investigate the possible association between serum copeptin and complications of liver cirrhosis, including its potential role as a stress biomarker in spontaneous bacterial peritonitis (SBP). MATERIAL AND METHODS: This cross-sectional study included 89 cirrhotic ascitic patients (37 with SBP and 52 without SBP) admitted to Sohag University Hospitals, Egypt, between June 2021 and February 2022. Serum copeptin was measured in all patients, and its association with SBP and other complications of liver cirrhosis was investigated. RESULTS: Serum copeptin was significantly elevated in patients with SBP compared to those without SBP (p = 0.032) and significantly correlated with ascitic fluid study parameters, systemic inflammatory markers, and liver, renal, and circulatory functions. Serum copeptin and C-reactive protein (CRP) were independent risk factors for the presence of SBP. Serum copeptin detects SBP at a cut-off value of 9 pmol/l, with sensitivity and specificity of 73% and 64%, respectively. Serum copeptin was significantly associated with hepatic encephalopathy, gastrointestinal bleeding, hepatorenal syndrome, and larger amounts of ascites. CONCLUSIONS: Serum copeptin is an independent risk factor for the presence of SBP and significantly increased in patients presented with major complications of liver cirrhosis, demonstrating its ability to reflect circulatory dysfunction and systemic inflammation. Termedia Publishing House 2023-03-21 2023-03 /pmc/articles/PMC10090990/ /pubmed/37064833 http://dx.doi.org/10.5114/ceh.2023.125970 Text en Copyright © 2023 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Abudeif, Ahmed Hashim, Marwa S. Ahmed, Nesma M. Ahmed, Ahmed Othman Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
title | Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
title_full | Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
title_fullStr | Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
title_full_unstemmed | Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
title_short | Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
title_sort | serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090990/ https://www.ncbi.nlm.nih.gov/pubmed/37064833 http://dx.doi.org/10.5114/ceh.2023.125970 |
work_keys_str_mv | AT abudeifahmed serumcopeptinisassociatedwithmajorcomplicationsoflivercirrhosisandspontaneousbacterialperitonitis AT hashimmarwas serumcopeptinisassociatedwithmajorcomplicationsoflivercirrhosisandspontaneousbacterialperitonitis AT ahmednesmam serumcopeptinisassociatedwithmajorcomplicationsoflivercirrhosisandspontaneousbacterialperitonitis AT ahmedahmedothman serumcopeptinisassociatedwithmajorcomplicationsoflivercirrhosisandspontaneousbacterialperitonitis |