Cargando…

Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout

INTRODUCTION: Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in p...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ze, He, Li, Jiao, Jiali, Jia, Junjie, Xing, Haifan, Zhou, Ting, Zhang, Qiming, Chen, Yini, Jiang, Lixin, Wang, Niansong, Fan, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091006/
https://www.ncbi.nlm.nih.gov/pubmed/37065606
http://dx.doi.org/10.1159/000528200
_version_ 1785023073263550464
author Li, Ze
He, Li
Jiao, Jiali
Jia, Junjie
Xing, Haifan
Zhou, Ting
Zhang, Qiming
Chen, Yini
Jiang, Lixin
Wang, Niansong
Fan, Ying
author_facet Li, Ze
He, Li
Jiao, Jiali
Jia, Junjie
Xing, Haifan
Zhou, Ting
Zhang, Qiming
Chen, Yini
Jiang, Lixin
Wang, Niansong
Fan, Ying
author_sort Li, Ze
collection PubMed
description INTRODUCTION: Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in patients with gout. METHODS: Clinical information, laboratory indicators, and MSUS findings were collected and compared between gout-only patients (gout − CKD) and gout patients with CKD (gout + CKD). Multivariate logistic regression was applied to identify risk factors for clinical and MSUS characteristics in both groups. Correlation analysis between MSUS signs and kidney-related indicators was performed, and the effects of MSUS characteristics on renal prognosis were evaluated. RESULTS: In total, 176 patients with gout were included, namely, 89 gout − CKD and 87 gout + CKD cases. After adjusting for confounders, the gout patients with CKD showed more frequent episodes in the previous year, higher ultrasound semiquantitative scores, and more tophi than gout patients without CKD. Additionally, the number of tophi, bone erosion, and synovial hypertrophy measured by MSUS was found to be negatively correlated with the eGFR. The existence of tophi was independently associated with an increased risk of a ≥10% decline in eGFR in the first-year follow-up (OR, 3.56; 95% CI, 1.382–9.176). CONCLUSIONS: Ultrasound-detected tophi, bone erosion, and synovial hypertrophy were associated with kidney injury in gout patients. The existence of tophi was associated with faster renal function deterioration. MSUS could be a potential auxiliary diagnostic method to evaluate kidney injury and predict renal outcome in gout patients.
format Online
Article
Text
id pubmed-10091006
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-100910062023-04-13 Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout Li, Ze He, Li Jiao, Jiali Jia, Junjie Xing, Haifan Zhou, Ting Zhang, Qiming Chen, Yini Jiang, Lixin Wang, Niansong Fan, Ying Kidney Dis (Basel) Research Article INTRODUCTION: Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in patients with gout. METHODS: Clinical information, laboratory indicators, and MSUS findings were collected and compared between gout-only patients (gout − CKD) and gout patients with CKD (gout + CKD). Multivariate logistic regression was applied to identify risk factors for clinical and MSUS characteristics in both groups. Correlation analysis between MSUS signs and kidney-related indicators was performed, and the effects of MSUS characteristics on renal prognosis were evaluated. RESULTS: In total, 176 patients with gout were included, namely, 89 gout − CKD and 87 gout + CKD cases. After adjusting for confounders, the gout patients with CKD showed more frequent episodes in the previous year, higher ultrasound semiquantitative scores, and more tophi than gout patients without CKD. Additionally, the number of tophi, bone erosion, and synovial hypertrophy measured by MSUS was found to be negatively correlated with the eGFR. The existence of tophi was independently associated with an increased risk of a ≥10% decline in eGFR in the first-year follow-up (OR, 3.56; 95% CI, 1.382–9.176). CONCLUSIONS: Ultrasound-detected tophi, bone erosion, and synovial hypertrophy were associated with kidney injury in gout patients. The existence of tophi was associated with faster renal function deterioration. MSUS could be a potential auxiliary diagnostic method to evaluate kidney injury and predict renal outcome in gout patients. S. Karger AG 2022-11-21 /pmc/articles/PMC10091006/ /pubmed/37065606 http://dx.doi.org/10.1159/000528200 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Li, Ze
He, Li
Jiao, Jiali
Jia, Junjie
Xing, Haifan
Zhou, Ting
Zhang, Qiming
Chen, Yini
Jiang, Lixin
Wang, Niansong
Fan, Ying
Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
title Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
title_full Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
title_fullStr Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
title_full_unstemmed Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
title_short Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
title_sort musculoskeletal ultrasound evaluates renal injury and predicts renal outcome in patients with gout
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091006/
https://www.ncbi.nlm.nih.gov/pubmed/37065606
http://dx.doi.org/10.1159/000528200
work_keys_str_mv AT lize musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT heli musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT jiaojiali musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT jiajunjie musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT xinghaifan musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT zhouting musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT zhangqiming musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT chenyini musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT jianglixin musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT wangniansong musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout
AT fanying musculoskeletalultrasoundevaluatesrenalinjuryandpredictsrenaloutcomeinpatientswithgout