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Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout
INTRODUCTION: Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091006/ https://www.ncbi.nlm.nih.gov/pubmed/37065606 http://dx.doi.org/10.1159/000528200 |
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author | Li, Ze He, Li Jiao, Jiali Jia, Junjie Xing, Haifan Zhou, Ting Zhang, Qiming Chen, Yini Jiang, Lixin Wang, Niansong Fan, Ying |
author_facet | Li, Ze He, Li Jiao, Jiali Jia, Junjie Xing, Haifan Zhou, Ting Zhang, Qiming Chen, Yini Jiang, Lixin Wang, Niansong Fan, Ying |
author_sort | Li, Ze |
collection | PubMed |
description | INTRODUCTION: Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in patients with gout. METHODS: Clinical information, laboratory indicators, and MSUS findings were collected and compared between gout-only patients (gout − CKD) and gout patients with CKD (gout + CKD). Multivariate logistic regression was applied to identify risk factors for clinical and MSUS characteristics in both groups. Correlation analysis between MSUS signs and kidney-related indicators was performed, and the effects of MSUS characteristics on renal prognosis were evaluated. RESULTS: In total, 176 patients with gout were included, namely, 89 gout − CKD and 87 gout + CKD cases. After adjusting for confounders, the gout patients with CKD showed more frequent episodes in the previous year, higher ultrasound semiquantitative scores, and more tophi than gout patients without CKD. Additionally, the number of tophi, bone erosion, and synovial hypertrophy measured by MSUS was found to be negatively correlated with the eGFR. The existence of tophi was independently associated with an increased risk of a ≥10% decline in eGFR in the first-year follow-up (OR, 3.56; 95% CI, 1.382–9.176). CONCLUSIONS: Ultrasound-detected tophi, bone erosion, and synovial hypertrophy were associated with kidney injury in gout patients. The existence of tophi was associated with faster renal function deterioration. MSUS could be a potential auxiliary diagnostic method to evaluate kidney injury and predict renal outcome in gout patients. |
format | Online Article Text |
id | pubmed-10091006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-100910062023-04-13 Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout Li, Ze He, Li Jiao, Jiali Jia, Junjie Xing, Haifan Zhou, Ting Zhang, Qiming Chen, Yini Jiang, Lixin Wang, Niansong Fan, Ying Kidney Dis (Basel) Research Article INTRODUCTION: Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of gout patients with CKD using musculoskeletal ultrasound (MSUS) and whether MSUS could be used as an auxiliary assessment to evaluate kidney injury and predict renal outcome in patients with gout. METHODS: Clinical information, laboratory indicators, and MSUS findings were collected and compared between gout-only patients (gout − CKD) and gout patients with CKD (gout + CKD). Multivariate logistic regression was applied to identify risk factors for clinical and MSUS characteristics in both groups. Correlation analysis between MSUS signs and kidney-related indicators was performed, and the effects of MSUS characteristics on renal prognosis were evaluated. RESULTS: In total, 176 patients with gout were included, namely, 89 gout − CKD and 87 gout + CKD cases. After adjusting for confounders, the gout patients with CKD showed more frequent episodes in the previous year, higher ultrasound semiquantitative scores, and more tophi than gout patients without CKD. Additionally, the number of tophi, bone erosion, and synovial hypertrophy measured by MSUS was found to be negatively correlated with the eGFR. The existence of tophi was independently associated with an increased risk of a ≥10% decline in eGFR in the first-year follow-up (OR, 3.56; 95% CI, 1.382–9.176). CONCLUSIONS: Ultrasound-detected tophi, bone erosion, and synovial hypertrophy were associated with kidney injury in gout patients. The existence of tophi was associated with faster renal function deterioration. MSUS could be a potential auxiliary diagnostic method to evaluate kidney injury and predict renal outcome in gout patients. S. Karger AG 2022-11-21 /pmc/articles/PMC10091006/ /pubmed/37065606 http://dx.doi.org/10.1159/000528200 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Research Article Li, Ze He, Li Jiao, Jiali Jia, Junjie Xing, Haifan Zhou, Ting Zhang, Qiming Chen, Yini Jiang, Lixin Wang, Niansong Fan, Ying Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout |
title | Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout |
title_full | Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout |
title_fullStr | Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout |
title_full_unstemmed | Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout |
title_short | Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout |
title_sort | musculoskeletal ultrasound evaluates renal injury and predicts renal outcome in patients with gout |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091006/ https://www.ncbi.nlm.nih.gov/pubmed/37065606 http://dx.doi.org/10.1159/000528200 |
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