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Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital

BACKGROUND: Urinary tract infections are common bacterial infections affecting millions worldwide. Although treatment options for urinary tract infections are well established, with ciprofloxacin long considered one of the antibiotics of choice, increasing antibiotic resistance may delay the initiat...

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Autores principales: Naidoo, Alicia, Kajee, Afsana, Mvelase, Nomonde R., Swe-Han, Khine Swe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091058/
https://www.ncbi.nlm.nih.gov/pubmed/37063604
http://dx.doi.org/10.4102/ajlm.v12i1.1920
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author Naidoo, Alicia
Kajee, Afsana
Mvelase, Nomonde R.
Swe-Han, Khine Swe
author_facet Naidoo, Alicia
Kajee, Afsana
Mvelase, Nomonde R.
Swe-Han, Khine Swe
author_sort Naidoo, Alicia
collection PubMed
description BACKGROUND: Urinary tract infections are common bacterial infections affecting millions worldwide. Although treatment options for urinary tract infections are well established, with ciprofloxacin long considered one of the antibiotics of choice, increasing antibiotic resistance may delay the initiation of appropriate therapy. While this increase in antimicrobial resistance has been demonstrated in multiple studies around the world, there is a dearth of information from developing countries. OBJECTIVE: This study aimed to describe the antimicrobial susceptibility patterns of commonly isolated bacterial uropathogens in a South African hospital. METHODS: Antimicrobial susceptibility data of isolates obtained from urine specimens at the RK Khan Hospital, a regional hospital in KwaZulu-Natal, South Africa, between January 2018 and December 2020 were retrieved from the hospital’s laboratory information system and analysed to determine the differences in resistance rates between the most frequently isolated bacterial uropathogens. RESULTS: Of the 3048 bacterial urinary pathogens isolated between 2018 and 2020, Escherichia coli (1603; 53%) was the most common, followed by Klebsiella spp. (437; 14%). Both E. coli and Klebsiella spp. showed high rates of resistance to amoxicillin/clavulanic acid (29.8% and 42.3%) and ciprofloxacin (37.7% and 30.4%). Nitrofurantoin resistance was low among E. coli (6.2%) but high among Klebsiella spp. (61.3%). CONCLUSION: E. coli and Klebsiella spp. in this study were highly resistant to amoxicillin/clavulanic acid and ciprofloxacin, two of the frequently prescribed oral treatment options. WHAT THIS STUDY ADDS: This study highlights the importance of regular local antimicrobial resistance surveillance to inform appropriate empiric therapy.
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spelling pubmed-100910582023-04-13 Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital Naidoo, Alicia Kajee, Afsana Mvelase, Nomonde R. Swe-Han, Khine Swe Afr J Lab Med Original Research BACKGROUND: Urinary tract infections are common bacterial infections affecting millions worldwide. Although treatment options for urinary tract infections are well established, with ciprofloxacin long considered one of the antibiotics of choice, increasing antibiotic resistance may delay the initiation of appropriate therapy. While this increase in antimicrobial resistance has been demonstrated in multiple studies around the world, there is a dearth of information from developing countries. OBJECTIVE: This study aimed to describe the antimicrobial susceptibility patterns of commonly isolated bacterial uropathogens in a South African hospital. METHODS: Antimicrobial susceptibility data of isolates obtained from urine specimens at the RK Khan Hospital, a regional hospital in KwaZulu-Natal, South Africa, between January 2018 and December 2020 were retrieved from the hospital’s laboratory information system and analysed to determine the differences in resistance rates between the most frequently isolated bacterial uropathogens. RESULTS: Of the 3048 bacterial urinary pathogens isolated between 2018 and 2020, Escherichia coli (1603; 53%) was the most common, followed by Klebsiella spp. (437; 14%). Both E. coli and Klebsiella spp. showed high rates of resistance to amoxicillin/clavulanic acid (29.8% and 42.3%) and ciprofloxacin (37.7% and 30.4%). Nitrofurantoin resistance was low among E. coli (6.2%) but high among Klebsiella spp. (61.3%). CONCLUSION: E. coli and Klebsiella spp. in this study were highly resistant to amoxicillin/clavulanic acid and ciprofloxacin, two of the frequently prescribed oral treatment options. WHAT THIS STUDY ADDS: This study highlights the importance of regular local antimicrobial resistance surveillance to inform appropriate empiric therapy. AOSIS 2023-03-03 /pmc/articles/PMC10091058/ /pubmed/37063604 http://dx.doi.org/10.4102/ajlm.v12i1.1920 Text en © 2023. The Authors https://creativecommons.org/licenses/by/4.0/Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Original Research
Naidoo, Alicia
Kajee, Afsana
Mvelase, Nomonde R.
Swe-Han, Khine Swe
Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital
title Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital
title_full Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital
title_fullStr Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital
title_full_unstemmed Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital
title_short Antimicrobial susceptibility of bacterial uropathogens in a South African regional hospital
title_sort antimicrobial susceptibility of bacterial uropathogens in a south african regional hospital
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091058/
https://www.ncbi.nlm.nih.gov/pubmed/37063604
http://dx.doi.org/10.4102/ajlm.v12i1.1920
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