Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer

BACKGROUND: Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown a moderate response in colorectal cancer (CRC) with deficient mismatch repair (dMMR) functions and poor response in patients with proficient MMR (pMMR). p...

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Detalles Bibliográficos
Autores principales: Liu, Chaofan, Wang, Xi, Qin, Wan, Tu, Jingyao, Li, Chunya, Zhao, Weiheng, Ma, Li, Liu, Bo, Qiu, Hong, Yuan, Xianglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091106/
https://www.ncbi.nlm.nih.gov/pubmed/36855844
http://dx.doi.org/10.1002/cac2.12412

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