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Role of adenosine A2a receptor in cancers and autoimmune diseases
Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine. Under pathological conditions or external stimuli, ATP is sequentially hyd...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091380/ https://www.ncbi.nlm.nih.gov/pubmed/37102661 http://dx.doi.org/10.1002/iid3.826 |
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author | Ye, Hongling Zhao, Junqi Xu, Xuejing Zhang, Dagan Shen, Han Wang, Sen |
author_facet | Ye, Hongling Zhao, Junqi Xu, Xuejing Zhang, Dagan Shen, Han Wang, Sen |
author_sort | Ye, Hongling |
collection | PubMed |
description | Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine. Under pathological conditions or external stimuli, ATP is sequentially hydrolyzed to adenosine by CD39 and CD73. The combination of adenosine and A2AR can increase the concentration of cAMP and activate a series of downstream signaling pathways, and further playing the role of immunosuppression and promotion of tumor invasion. A2AR is expressed to some extent on various immune cells, where it is abnormally expressed on immune cells in cancers and autoimmune diseases. A2AR expression also correlates with disease progression. Inhibitors and agonists of A2AR may be potential new strategies for treatment of cancers and autoimmune diseases. We herein briefly reviewed the expression and distribution of A2AR, adenosine/A2AR signaling pathway, expression, and potential as a therapeutic target. |
format | Online Article Text |
id | pubmed-10091380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100913802023-04-13 Role of adenosine A2a receptor in cancers and autoimmune diseases Ye, Hongling Zhao, Junqi Xu, Xuejing Zhang, Dagan Shen, Han Wang, Sen Immun Inflamm Dis Review Articles Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine. Under pathological conditions or external stimuli, ATP is sequentially hydrolyzed to adenosine by CD39 and CD73. The combination of adenosine and A2AR can increase the concentration of cAMP and activate a series of downstream signaling pathways, and further playing the role of immunosuppression and promotion of tumor invasion. A2AR is expressed to some extent on various immune cells, where it is abnormally expressed on immune cells in cancers and autoimmune diseases. A2AR expression also correlates with disease progression. Inhibitors and agonists of A2AR may be potential new strategies for treatment of cancers and autoimmune diseases. We herein briefly reviewed the expression and distribution of A2AR, adenosine/A2AR signaling pathway, expression, and potential as a therapeutic target. John Wiley and Sons Inc. 2023-04-12 /pmc/articles/PMC10091380/ /pubmed/37102661 http://dx.doi.org/10.1002/iid3.826 Text en © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Ye, Hongling Zhao, Junqi Xu, Xuejing Zhang, Dagan Shen, Han Wang, Sen Role of adenosine A2a receptor in cancers and autoimmune diseases |
title | Role of adenosine A2a receptor in cancers and autoimmune diseases |
title_full | Role of adenosine A2a receptor in cancers and autoimmune diseases |
title_fullStr | Role of adenosine A2a receptor in cancers and autoimmune diseases |
title_full_unstemmed | Role of adenosine A2a receptor in cancers and autoimmune diseases |
title_short | Role of adenosine A2a receptor in cancers and autoimmune diseases |
title_sort | role of adenosine a2a receptor in cancers and autoimmune diseases |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091380/ https://www.ncbi.nlm.nih.gov/pubmed/37102661 http://dx.doi.org/10.1002/iid3.826 |
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