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Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers

BACKGROUND: FBXW7 is recognized as a critical tumor suppressor gene and a component of the ubiquitin-proteasome system, mediating the degradation of multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% of colorectal cancer (CRC) patients carried FBXW7 somatic mutatio...

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Detalles Bibliográficos
Autores principales:	Liu, Yiping, Chen, Hanlin, Bao, Hua, Zhang, Jinfeng, Wu, Runda, Zhu, Lingjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091464/ https://www.ncbi.nlm.nih.gov/pubmed/37064111 http://dx.doi.org/10.3389/fonc.2023.1154432

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