FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

PURPOSE: The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy in PDAC patients, further improvement is needed. One of the major obstacles might...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yifan, Sun, Yansha, Wang, Peng, Li, Songling, Dong, Yiwei, Zhou, Min, Shi, Bizhi, Jiang, Hua, Sun, Ruixin, Li, Zonghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091631/
https://www.ncbi.nlm.nih.gov/pubmed/37046312
http://dx.doi.org/10.1186/s12967-023-04080-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091631/
https://www.ncbi.nlm.nih.gov/pubmed/37046312
http://dx.doi.org/10.1186/s12967-023-04080-z

Ejemplares similares