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FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

PURPOSE: The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy in PDAC patients, further improvement is needed. One of the major obstacles might...

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Detalles Bibliográficos
Autores principales:	Liu, Yifan, Sun, Yansha, Wang, Peng, Li, Songling, Dong, Yiwei, Zhou, Min, Shi, Bizhi, Jiang, Hua, Sun, Ruixin, Li, Zonghai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091631/ https://www.ncbi.nlm.nih.gov/pubmed/37046312 http://dx.doi.org/10.1186/s12967-023-04080-z

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