Development of an antibody-ligand fusion protein scFvCD16A(-)sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells

BACKGROUND: Natural killer (NK) cell-based immunotherapies have demonstrated substantial potential for the treatment of hematologic malignancies. However, its application is limited due to the difficulty in the production of a large number of NK cells in vitro and the insufficient therapeutic effica...

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Detalles Bibliográficos
Autores principales: Li, Yangyang, Xie, Siqi, Chen, Minhua, Li, Hao, Wang, Yehai, Fan, Yan, An, Kang, Wu, Yu, Xiao, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091686/
https://www.ncbi.nlm.nih.gov/pubmed/37041591
http://dx.doi.org/10.1186/s12934-023-02082-6

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