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The peritumoral brain zone in glioblastoma: where we are and where we are going

Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal b...

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Autores principales: Giambra, Martina, Di Cristofori, Andrea, Valtorta, Silvia, Manfrellotti, Roberto, Bigiogera, Vittorio, Basso, Gianpaolo, Moresco, Rosa Maria, Giussani, Carlo, Bentivegna, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091804/
https://www.ncbi.nlm.nih.gov/pubmed/36300592
http://dx.doi.org/10.1002/jnr.25134
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author Giambra, Martina
Di Cristofori, Andrea
Valtorta, Silvia
Manfrellotti, Roberto
Bigiogera, Vittorio
Basso, Gianpaolo
Moresco, Rosa Maria
Giussani, Carlo
Bentivegna, Angela
author_facet Giambra, Martina
Di Cristofori, Andrea
Valtorta, Silvia
Manfrellotti, Roberto
Bigiogera, Vittorio
Basso, Gianpaolo
Moresco, Rosa Maria
Giussani, Carlo
Bentivegna, Angela
author_sort Giambra, Martina
collection PubMed
description Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is expected to appear in the majority of cases. Thus, in the last decades, an increased interest has developed to investigate the cellular and molecular interactions between GBM and the peritumoral brain zone (PBZ) bordering the tumor tissue. The aim of this review is to provide up‐to‐date knowledge about the oncogenic properties of the PBZ to highlight possible druggable targets for more effective treatment of GBM by limiting the formation of recurrence, which is almost inevitable in the majority of patients. Starting from the description of the cellular components, passing through the illustration of the molecular profiles, we finally focused on more clinical aspects, represented by imaging and radiological details. The complete picture that emerges from this review could provide new input for future investigations aimed at identifying new effective strategies to eradicate this still incurable tumor.
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spelling pubmed-100918042023-04-13 The peritumoral brain zone in glioblastoma: where we are and where we are going Giambra, Martina Di Cristofori, Andrea Valtorta, Silvia Manfrellotti, Roberto Bigiogera, Vittorio Basso, Gianpaolo Moresco, Rosa Maria Giussani, Carlo Bentivegna, Angela J Neurosci Res Review Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is expected to appear in the majority of cases. Thus, in the last decades, an increased interest has developed to investigate the cellular and molecular interactions between GBM and the peritumoral brain zone (PBZ) bordering the tumor tissue. The aim of this review is to provide up‐to‐date knowledge about the oncogenic properties of the PBZ to highlight possible druggable targets for more effective treatment of GBM by limiting the formation of recurrence, which is almost inevitable in the majority of patients. Starting from the description of the cellular components, passing through the illustration of the molecular profiles, we finally focused on more clinical aspects, represented by imaging and radiological details. The complete picture that emerges from this review could provide new input for future investigations aimed at identifying new effective strategies to eradicate this still incurable tumor. John Wiley and Sons Inc. 2022-10-27 2023-02 /pmc/articles/PMC10091804/ /pubmed/36300592 http://dx.doi.org/10.1002/jnr.25134 Text en © 2022 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Giambra, Martina
Di Cristofori, Andrea
Valtorta, Silvia
Manfrellotti, Roberto
Bigiogera, Vittorio
Basso, Gianpaolo
Moresco, Rosa Maria
Giussani, Carlo
Bentivegna, Angela
The peritumoral brain zone in glioblastoma: where we are and where we are going
title The peritumoral brain zone in glioblastoma: where we are and where we are going
title_full The peritumoral brain zone in glioblastoma: where we are and where we are going
title_fullStr The peritumoral brain zone in glioblastoma: where we are and where we are going
title_full_unstemmed The peritumoral brain zone in glioblastoma: where we are and where we are going
title_short The peritumoral brain zone in glioblastoma: where we are and where we are going
title_sort peritumoral brain zone in glioblastoma: where we are and where we are going
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091804/
https://www.ncbi.nlm.nih.gov/pubmed/36300592
http://dx.doi.org/10.1002/jnr.25134
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