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Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells

Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH. However, there is evidence that l‐citrulline might increase arginase activity, which in turn, has bee...

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Detalles Bibliográficos
Autores principales:	Douglass, Matthew S., Kaplowitz, Mark R., Zhang, Yongmei, Fike, Candice D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091859/ https://www.ncbi.nlm.nih.gov/pubmed/37063746 http://dx.doi.org/10.1002/pul2.12221

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