Cargando…

Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis

INTRODUCTION: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Hongxia, Zhang, Shaofang, Lin, Lin, Rastogi, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091918/
https://www.ncbi.nlm.nih.gov/pubmed/37064561
http://dx.doi.org/10.5114/wiitm.2022.120768
_version_ 1785023227431485440
author Li, Hongxia
Zhang, Shaofang
Lin, Lin
Rastogi, Sanjay
author_facet Li, Hongxia
Zhang, Shaofang
Lin, Lin
Rastogi, Sanjay
author_sort Li, Hongxia
collection PubMed
description INTRODUCTION: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be of much help, and hence valid conclusions about its role are still unclear. AIM: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC). MATERIAL AND METHODS: Appropriate articles were searched from the PubMed, Medline, and Central databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective, and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for the effect of EIN on patients undergoing surgery for GC were extracted from the included studies. RESULTS: Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a τ(2) value of 2.77, a χ(2) value of 1707.96, a df value of 11, an I(2) value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of τ(2) value of 0.73, χ(2) value of 1428.34, df value of 11, I(2) value of 99%, z value of 2.99, and p-value < 0.05. CONCLUSIONS: The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer (GC) patients undergoing gastrectomy.
format Online
Article
Text
id pubmed-10091918
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-100919182023-04-13 Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis Li, Hongxia Zhang, Shaofang Lin, Lin Rastogi, Sanjay Wideochir Inne Tech Maloinwazyjne Meta-Analysis INTRODUCTION: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be of much help, and hence valid conclusions about its role are still unclear. AIM: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC). MATERIAL AND METHODS: Appropriate articles were searched from the PubMed, Medline, and Central databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective, and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for the effect of EIN on patients undergoing surgery for GC were extracted from the included studies. RESULTS: Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a τ(2) value of 2.77, a χ(2) value of 1707.96, a df value of 11, an I(2) value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of τ(2) value of 0.73, χ(2) value of 1428.34, df value of 11, I(2) value of 99%, z value of 2.99, and p-value < 0.05. CONCLUSIONS: The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer (GC) patients undergoing gastrectomy. Termedia Publishing House 2022-11-02 2023-03 /pmc/articles/PMC10091918/ /pubmed/37064561 http://dx.doi.org/10.5114/wiitm.2022.120768 Text en Copyright: © 2022 Fundacja Videochirurgii https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Meta-Analysis
Li, Hongxia
Zhang, Shaofang
Lin, Lin
Rastogi, Sanjay
Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
title Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
title_full Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
title_fullStr Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
title_full_unstemmed Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
title_short Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
title_sort does enteral immune nutrition (ein) boost the immunity of gastric cancer (gc) patients undergoing surgery? a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091918/
https://www.ncbi.nlm.nih.gov/pubmed/37064561
http://dx.doi.org/10.5114/wiitm.2022.120768
work_keys_str_mv AT lihongxia doesenteralimmunenutritioneinboosttheimmunityofgastriccancergcpatientsundergoingsurgeryasystematicreviewandmetaanalysis
AT zhangshaofang doesenteralimmunenutritioneinboosttheimmunityofgastriccancergcpatientsundergoingsurgeryasystematicreviewandmetaanalysis
AT linlin doesenteralimmunenutritioneinboosttheimmunityofgastriccancergcpatientsundergoingsurgeryasystematicreviewandmetaanalysis
AT rastogisanjay doesenteralimmunenutritioneinboosttheimmunityofgastriccancergcpatientsundergoingsurgeryasystematicreviewandmetaanalysis