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Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis
INTRODUCTION: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091918/ https://www.ncbi.nlm.nih.gov/pubmed/37064561 http://dx.doi.org/10.5114/wiitm.2022.120768 |
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author | Li, Hongxia Zhang, Shaofang Lin, Lin Rastogi, Sanjay |
author_facet | Li, Hongxia Zhang, Shaofang Lin, Lin Rastogi, Sanjay |
author_sort | Li, Hongxia |
collection | PubMed |
description | INTRODUCTION: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be of much help, and hence valid conclusions about its role are still unclear. AIM: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC). MATERIAL AND METHODS: Appropriate articles were searched from the PubMed, Medline, and Central databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective, and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for the effect of EIN on patients undergoing surgery for GC were extracted from the included studies. RESULTS: Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a τ(2) value of 2.77, a χ(2) value of 1707.96, a df value of 11, an I(2) value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of τ(2) value of 0.73, χ(2) value of 1428.34, df value of 11, I(2) value of 99%, z value of 2.99, and p-value < 0.05. CONCLUSIONS: The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer (GC) patients undergoing gastrectomy. |
format | Online Article Text |
id | pubmed-10091918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-100919182023-04-13 Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis Li, Hongxia Zhang, Shaofang Lin, Lin Rastogi, Sanjay Wideochir Inne Tech Maloinwazyjne Meta-Analysis INTRODUCTION: The main components of enteral immunonutrition (EIN) are ω-3 fatty acids, glutamine, arginine, and nucleotide, which primarily raises the immunity of the host and helps to reduce postoperative infections and non-infectious difficulties. Although the potential benefits of EIN are widely reported, some researchers did not find it to be of much help, and hence valid conclusions about its role are still unclear. AIM: To evaluate the role of enteral immunonutrition on patients undergoing surgery for gastric cancer (GC). MATERIAL AND METHODS: Appropriate articles were searched from the PubMed, Medline, and Central databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials, and retrospective, prospective, and open-label studies were included as per the predefined PICOS criteria. Demographic summary and event data for the effect of EIN on patients undergoing surgery for GC were extracted from the included studies. RESULTS: Twelve randomized controlled clinical trials with a total of 10,422 gastric cancer patients were included. We found the odds ratio value of 0.23 (95% CI: 0.09–0.59). The results are heterogeneous with a τ(2) value of 2.77, a χ(2) value of 1707.96, a df value of 11, an I(2) value of 99%, a z value of 3.04, and a p-value of less than 0.05. The risk ratio is 0.47 (95% CI: 0.29–0.77) with heterogeneity of τ(2) value of 0.73, χ(2) value of 1428.34, df value of 11, I(2) value of 99%, z value of 2.99, and p-value < 0.05. CONCLUSIONS: The present meta-analysis strongly commends the use of EIN to boost the immunity of gastric cancer (GC) patients undergoing gastrectomy. Termedia Publishing House 2022-11-02 2023-03 /pmc/articles/PMC10091918/ /pubmed/37064561 http://dx.doi.org/10.5114/wiitm.2022.120768 Text en Copyright: © 2022 Fundacja Videochirurgii https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Meta-Analysis Li, Hongxia Zhang, Shaofang Lin, Lin Rastogi, Sanjay Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
title | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
title_full | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
title_fullStr | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
title_full_unstemmed | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
title_short | Does enteral immune nutrition (EIN) boost the immunity of gastric cancer (GC) patients undergoing surgery? A systematic review and meta-analysis |
title_sort | does enteral immune nutrition (ein) boost the immunity of gastric cancer (gc) patients undergoing surgery? a systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091918/ https://www.ncbi.nlm.nih.gov/pubmed/37064561 http://dx.doi.org/10.5114/wiitm.2022.120768 |
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