Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes

BACKGROUND AND PURPOSE: Small interfering RNA (siRNA) targeting liver angiotensinogen lowers blood pressure, but its effects in hypertensive diabetes are unknown. EXPERIMENTAL APPROACH: To address this, TGR (mRen2)27 rats (angiotensin II‐dependent hypertension model) were made diabetic with streptoz...

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Detalles Bibliográficos
Autores principales: Cruz‐López, Edwyn O., Ren, Liwei, Uijl, Estrellita, Clahsen‐van Groningen, Marian C., van Veghel, Richard, Garrelds, Ingrid M., Domenig, Oliver, Poglitsch, Marko, Zlatev, Ivan, Rooney, Timothy, Kasper, Anne, Nioi, Paul, Foster, Don, Danser, A. H. Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091936/
https://www.ncbi.nlm.nih.gov/pubmed/36106615
http://dx.doi.org/10.1111/bph.15955

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