Cargando…
Recent Developments and Trends in Asymmetric Organocatalysis
Asymmetric organocatalysis has experienced a long and spectacular way since the early reports over a century ago by von Liebig, Knoevenagel and Bredig, showing that small (chiral) organic molecules can catalyze (asymmetric) reactions. This was followed by impressive first highly enantioselective rep...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091998/ https://www.ncbi.nlm.nih.gov/pubmed/37065706 http://dx.doi.org/10.1002/ejoc.202200950 |
_version_ | 1785023244911247360 |
---|---|
author | García Mancheño, Olga Waser, Mario |
author_facet | García Mancheño, Olga Waser, Mario |
author_sort | García Mancheño, Olga |
collection | PubMed |
description | Asymmetric organocatalysis has experienced a long and spectacular way since the early reports over a century ago by von Liebig, Knoevenagel and Bredig, showing that small (chiral) organic molecules can catalyze (asymmetric) reactions. This was followed by impressive first highly enantioselective reports in the second half of the last century, until the hype initiated in 2000 by the milestone publications of MacMillan and List, which finally culminated in the 2021 Nobel Prize in Chemistry. This short Perspective aims at providing a brief introduction to the field by first looking on the historical development and the more classical methods and concepts, followed by discussing selected advanced recent examples that opened new directions and diversity within this still growing field. |
format | Online Article Text |
id | pubmed-10091998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100919982023-04-13 Recent Developments and Trends in Asymmetric Organocatalysis García Mancheño, Olga Waser, Mario European J Org Chem Perspectives Asymmetric organocatalysis has experienced a long and spectacular way since the early reports over a century ago by von Liebig, Knoevenagel and Bredig, showing that small (chiral) organic molecules can catalyze (asymmetric) reactions. This was followed by impressive first highly enantioselective reports in the second half of the last century, until the hype initiated in 2000 by the milestone publications of MacMillan and List, which finally culminated in the 2021 Nobel Prize in Chemistry. This short Perspective aims at providing a brief introduction to the field by first looking on the historical development and the more classical methods and concepts, followed by discussing selected advanced recent examples that opened new directions and diversity within this still growing field. John Wiley and Sons Inc. 2022-10-17 2023-01-02 /pmc/articles/PMC10091998/ /pubmed/37065706 http://dx.doi.org/10.1002/ejoc.202200950 Text en © 2022 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspectives García Mancheño, Olga Waser, Mario Recent Developments and Trends in Asymmetric Organocatalysis |
title | Recent Developments and Trends in Asymmetric Organocatalysis |
title_full | Recent Developments and Trends in Asymmetric Organocatalysis |
title_fullStr | Recent Developments and Trends in Asymmetric Organocatalysis |
title_full_unstemmed | Recent Developments and Trends in Asymmetric Organocatalysis |
title_short | Recent Developments and Trends in Asymmetric Organocatalysis |
title_sort | recent developments and trends in asymmetric organocatalysis |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091998/ https://www.ncbi.nlm.nih.gov/pubmed/37065706 http://dx.doi.org/10.1002/ejoc.202200950 |
work_keys_str_mv | AT garciamanchenoolga recentdevelopmentsandtrendsinasymmetricorganocatalysis AT wasermario recentdevelopmentsandtrendsinasymmetricorganocatalysis |