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Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)
BACKGROUND: The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. METHODS: This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature. RESULTS:...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092073/ https://www.ncbi.nlm.nih.gov/pubmed/36300896 http://dx.doi.org/10.1111/jmp.12622 |
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author | Li, Xiantang Santos, Rosemary Bernal, Jan E. Li, Dingzhou D. Hargaden, Maureen Khan, Nasir K. |
author_facet | Li, Xiantang Santos, Rosemary Bernal, Jan E. Li, Dingzhou D. Hargaden, Maureen Khan, Nasir K. |
author_sort | Li, Xiantang |
collection | PubMed |
description | BACKGROUND: The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. METHODS: This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature. RESULTS: The cynomolgus macaque is born precocious relative to humans in some organ systems (e.g., nervous, skeletal, respiratory, and gastrointestinal). Organ systems develop, refine, and expand at different rates after birth. In general, the respiratory, gastrointestinal, renal, and hematopoietic systems mature at approximately 3 years of age. The female reproductive, cardiovascular and hepatobiliary systems mature at approximately 4 years of age. The central nervous, skeletal, immune, male reproductive, and endocrine systems complete their development at approximately 5 to 9 years of age. CONCLUSIONS: The cynomolgus macaque has no meaningful developmental differences in critical organ systems between 2 and 3 years of age for use in nonclinical safety assessment. |
format | Online Article Text |
id | pubmed-10092073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100920732023-04-13 Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) Li, Xiantang Santos, Rosemary Bernal, Jan E. Li, Dingzhou D. Hargaden, Maureen Khan, Nasir K. J Med Primatol Review BACKGROUND: The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. METHODS: This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature. RESULTS: The cynomolgus macaque is born precocious relative to humans in some organ systems (e.g., nervous, skeletal, respiratory, and gastrointestinal). Organ systems develop, refine, and expand at different rates after birth. In general, the respiratory, gastrointestinal, renal, and hematopoietic systems mature at approximately 3 years of age. The female reproductive, cardiovascular and hepatobiliary systems mature at approximately 4 years of age. The central nervous, skeletal, immune, male reproductive, and endocrine systems complete their development at approximately 5 to 9 years of age. CONCLUSIONS: The cynomolgus macaque has no meaningful developmental differences in critical organ systems between 2 and 3 years of age for use in nonclinical safety assessment. John Wiley and Sons Inc. 2022-10-27 2023-02 /pmc/articles/PMC10092073/ /pubmed/36300896 http://dx.doi.org/10.1111/jmp.12622 Text en © 2022 Pfizer Inc. Journal of Medical Primatology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Li, Xiantang Santos, Rosemary Bernal, Jan E. Li, Dingzhou D. Hargaden, Maureen Khan, Nasir K. Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) |
title | Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) |
title_full | Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) |
title_fullStr | Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) |
title_full_unstemmed | Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) |
title_short | Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis) |
title_sort | biology and postnatal development of organ systems of cynomolgus monkeys (macaca fascicularis) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092073/ https://www.ncbi.nlm.nih.gov/pubmed/36300896 http://dx.doi.org/10.1111/jmp.12622 |
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