A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes

The engagement in tandem of well‐known organic reactions such as the Pd‐catalyzed Sonogashira cross‐coupling reaction, nucleophilic substitution and elimination reactions, enables the synthesis of otherwise difficult to obtain linear dienynes, in moderate to high yields. This retrosynthetic approach...

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Autores principales: Lumbreras‐Teijeiro, Alejandro, Bacic, Matea, Oliver‐Meseguer, Judit, Leyva‐Pérez, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092193/
https://www.ncbi.nlm.nih.gov/pubmed/36134576
http://dx.doi.org/10.1002/chem.202202421
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author Lumbreras‐Teijeiro, Alejandro
Bacic, Matea
Oliver‐Meseguer, Judit
Leyva‐Pérez, Antonio
author_facet Lumbreras‐Teijeiro, Alejandro
Bacic, Matea
Oliver‐Meseguer, Judit
Leyva‐Pérez, Antonio
author_sort Lumbreras‐Teijeiro, Alejandro
collection PubMed
description The engagement in tandem of well‐known organic reactions such as the Pd‐catalyzed Sonogashira cross‐coupling reaction, nucleophilic substitution and elimination reactions, enables the synthesis of otherwise difficult to obtain linear dienynes, in moderate to high yields. This retrosynthetic approach opens new ways to prepare highly conjugated alkenes and alkynes. Furthermore, ionic liquids are suitable solvents to perform the cascade reaction and recycle the metal catalysts.
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spelling pubmed-100921932023-04-13 A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes Lumbreras‐Teijeiro, Alejandro Bacic, Matea Oliver‐Meseguer, Judit Leyva‐Pérez, Antonio Chemistry Research Articles The engagement in tandem of well‐known organic reactions such as the Pd‐catalyzed Sonogashira cross‐coupling reaction, nucleophilic substitution and elimination reactions, enables the synthesis of otherwise difficult to obtain linear dienynes, in moderate to high yields. This retrosynthetic approach opens new ways to prepare highly conjugated alkenes and alkynes. Furthermore, ionic liquids are suitable solvents to perform the cascade reaction and recycle the metal catalysts. John Wiley and Sons Inc. 2022-10-31 2022-12-20 /pmc/articles/PMC10092193/ /pubmed/36134576 http://dx.doi.org/10.1002/chem.202202421 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Lumbreras‐Teijeiro, Alejandro
Bacic, Matea
Oliver‐Meseguer, Judit
Leyva‐Pérez, Antonio
A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes
title A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes
title_full A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes
title_fullStr A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes
title_full_unstemmed A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes
title_short A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes
title_sort cascade sonogashira cross‐coupling‐substitution‐elimination reaction for the synthesis of linear conjugated dienynes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092193/
https://www.ncbi.nlm.nih.gov/pubmed/36134576
http://dx.doi.org/10.1002/chem.202202421
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