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Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey
OBJECTIVES: Inflammatory bowel disease (IBD) can affect young and reproductively active patients. Our aim was to analyze pregnancy outcomes in a large cohort of women with IBD. METHODS: All women with at least one pregnancy were given a questionnaire regarding the outcome of their pregnancy. They we...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092249/ https://www.ncbi.nlm.nih.gov/pubmed/36156857 http://dx.doi.org/10.1111/1751-2980.13128 |
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author | Innocenti, Tommaso Roselli, Jenny Taylor, Alice Dragoni, Gabriele Lynch, Erica Nicola Campani, Claudia Gottin, Matteo Bagnoli, Siro Macrì, Giuseppe Rogai, Francesca Milani, Stefano Galli, Andrea Milla, Monica |
author_facet | Innocenti, Tommaso Roselli, Jenny Taylor, Alice Dragoni, Gabriele Lynch, Erica Nicola Campani, Claudia Gottin, Matteo Bagnoli, Siro Macrì, Giuseppe Rogai, Francesca Milani, Stefano Galli, Andrea Milla, Monica |
author_sort | Innocenti, Tommaso |
collection | PubMed |
description | OBJECTIVES: Inflammatory bowel disease (IBD) can affect young and reproductively active patients. Our aim was to analyze pregnancy outcomes in a large cohort of women with IBD. METHODS: All women with at least one pregnancy were given a questionnaire regarding the outcome of their pregnancy. They were divided into IBD pregnancies and controls depending on whether pregnancy occurred within or over 10 years prior to the diagnosis of IBD. RESULTS: Three hundred questionnaires were analyzed for a total of 478 pregnancies that led to live‐born babies. Age at conception was older in IBD women than in the controls. Active smoking was more frequent in the control group. The risk of intrauterine growth restriction (IUGR) was higher in IBD pregnancies (odds ratio [OR] 3.028, 95% confidence interval [CI] 1.245–7.370, P = 0.013). The week of gestation at delivery was lower in the IBD population. And the risk of cesarean section was higher in IBD pregnancies (OR 1.963, 95% CI 1.274–3.028, P = 0.002). Among women with IBD pregnancy, the risk of preterm birth was higher in patients with active disease at the time of conception (OR 4.088, 95% CI 1.112–15.025, P = 0.030), but lower in patients who continued regular therapy during pregnancy. Similarly, the risk of urgent cesarean section was reduced in the case of disease remission, while the risk of a planned cesarean delivery was higher in patients with perianal disease (OR 11.314, 95% CI 3.550–36.058, P < 0.01). CONCLUSIONS: Our study shows a higher risk of IUGR, cesarean section, and poor blood pressure control in IBD pregnancies. We emphasize the importance of achieving disease remission before considering pregnancy. |
format | Online Article Text |
id | pubmed-10092249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-100922492023-04-13 Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey Innocenti, Tommaso Roselli, Jenny Taylor, Alice Dragoni, Gabriele Lynch, Erica Nicola Campani, Claudia Gottin, Matteo Bagnoli, Siro Macrì, Giuseppe Rogai, Francesca Milani, Stefano Galli, Andrea Milla, Monica J Dig Dis ORIGINAL ARTICLES OBJECTIVES: Inflammatory bowel disease (IBD) can affect young and reproductively active patients. Our aim was to analyze pregnancy outcomes in a large cohort of women with IBD. METHODS: All women with at least one pregnancy were given a questionnaire regarding the outcome of their pregnancy. They were divided into IBD pregnancies and controls depending on whether pregnancy occurred within or over 10 years prior to the diagnosis of IBD. RESULTS: Three hundred questionnaires were analyzed for a total of 478 pregnancies that led to live‐born babies. Age at conception was older in IBD women than in the controls. Active smoking was more frequent in the control group. The risk of intrauterine growth restriction (IUGR) was higher in IBD pregnancies (odds ratio [OR] 3.028, 95% confidence interval [CI] 1.245–7.370, P = 0.013). The week of gestation at delivery was lower in the IBD population. And the risk of cesarean section was higher in IBD pregnancies (OR 1.963, 95% CI 1.274–3.028, P = 0.002). Among women with IBD pregnancy, the risk of preterm birth was higher in patients with active disease at the time of conception (OR 4.088, 95% CI 1.112–15.025, P = 0.030), but lower in patients who continued regular therapy during pregnancy. Similarly, the risk of urgent cesarean section was reduced in the case of disease remission, while the risk of a planned cesarean delivery was higher in patients with perianal disease (OR 11.314, 95% CI 3.550–36.058, P < 0.01). CONCLUSIONS: Our study shows a higher risk of IUGR, cesarean section, and poor blood pressure control in IBD pregnancies. We emphasize the importance of achieving disease remission before considering pregnancy. Wiley Publishing Asia Pty Ltd 2022-10-31 2022 /pmc/articles/PMC10092249/ /pubmed/36156857 http://dx.doi.org/10.1111/1751-2980.13128 Text en © 2022 The Authors. Journal of Digestive Diseases published by Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | ORIGINAL ARTICLES Innocenti, Tommaso Roselli, Jenny Taylor, Alice Dragoni, Gabriele Lynch, Erica Nicola Campani, Claudia Gottin, Matteo Bagnoli, Siro Macrì, Giuseppe Rogai, Francesca Milani, Stefano Galli, Andrea Milla, Monica Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey |
title | Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey |
title_full | Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey |
title_fullStr | Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey |
title_full_unstemmed | Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey |
title_short | Pregnancy outcomes in inflammatory bowel disease: Data from a large cohort survey |
title_sort | pregnancy outcomes in inflammatory bowel disease: data from a large cohort survey |
topic | ORIGINAL ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092249/ https://www.ncbi.nlm.nih.gov/pubmed/36156857 http://dx.doi.org/10.1111/1751-2980.13128 |
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