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Influence of force field choice on the conformational landscape of rat and human islet amyloid polypeptide

Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein (IDP) whose abnormal aggregation into toxic soluble oligomers and insoluble amyloid fibrils is a pathological feature in type‐2 diabetes. Rat IAPP (rIAPP) differs from hIAPP by only six amino acids yet...

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Detalles Bibliográficos
Autores principales:	Moore, Sandra J., Deplazes, Evelyne, Mancera, Ricardo L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092333/ https://www.ncbi.nlm.nih.gov/pubmed/36163697 http://dx.doi.org/10.1002/prot.26432

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