Depressive symptoms and mortality‐findings from Helsinki birth cohort study

BACKGROUND: Individuals with depression and depressive symptoms have a higher mortality rate than non‐depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes,...

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Autores principales: Eriksson, Mia D., Eriksson, Johan G., Korhonen, Päivi, Koponen, Hannu, Salonen, Minna K., Mikkola, Tuija M., Kajantie, Eero, Wasenius, Niko S., von Bonsdorff, Mikaela, Kautiainen, Hannu, Laine, Merja K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092352/
https://www.ncbi.nlm.nih.gov/pubmed/36263580
http://dx.doi.org/10.1111/acps.13512
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author Eriksson, Mia D.
Eriksson, Johan G.
Korhonen, Päivi
Koponen, Hannu
Salonen, Minna K.
Mikkola, Tuija M.
Kajantie, Eero
Wasenius, Niko S.
von Bonsdorff, Mikaela
Kautiainen, Hannu
Laine, Merja K.
author_facet Eriksson, Mia D.
Eriksson, Johan G.
Korhonen, Päivi
Koponen, Hannu
Salonen, Minna K.
Mikkola, Tuija M.
Kajantie, Eero
Wasenius, Niko S.
von Bonsdorff, Mikaela
Kautiainen, Hannu
Laine, Merja K.
author_sort Eriksson, Mia D.
collection PubMed
description BACKGROUND: Individuals with depression and depressive symptoms have a higher mortality rate than non‐depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non‐melancholic, may provide some explanation to this phenomenon. METHODS: One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. RESULTS: Participants were followed up for a total of 28,044 person‐years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02–2.20)] when compared to the non‐depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non‐melancholic [1.11 (95% CI: 0.85–1.44)] and melancholic depressive [1.26 (95% CI: 0.87–1.81)] groups had higher mortality than the non‐depressive group [0.82 (95% CI: 0.73–0.93)]. CONCLUSIONS: Melancholic depressive symptoms are most strongly related to a higher mortality risk.
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spelling pubmed-100923522023-04-13 Depressive symptoms and mortality‐findings from Helsinki birth cohort study Eriksson, Mia D. Eriksson, Johan G. Korhonen, Päivi Koponen, Hannu Salonen, Minna K. Mikkola, Tuija M. Kajantie, Eero Wasenius, Niko S. von Bonsdorff, Mikaela Kautiainen, Hannu Laine, Merja K. Acta Psychiatr Scand Original Articles BACKGROUND: Individuals with depression and depressive symptoms have a higher mortality rate than non‐depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non‐melancholic, may provide some explanation to this phenomenon. METHODS: One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. RESULTS: Participants were followed up for a total of 28,044 person‐years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02–2.20)] when compared to the non‐depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non‐melancholic [1.11 (95% CI: 0.85–1.44)] and melancholic depressive [1.26 (95% CI: 0.87–1.81)] groups had higher mortality than the non‐depressive group [0.82 (95% CI: 0.73–0.93)]. CONCLUSIONS: Melancholic depressive symptoms are most strongly related to a higher mortality risk. John Wiley and Sons Inc. 2022-11-01 2023-02 /pmc/articles/PMC10092352/ /pubmed/36263580 http://dx.doi.org/10.1111/acps.13512 Text en © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Eriksson, Mia D.
Eriksson, Johan G.
Korhonen, Päivi
Koponen, Hannu
Salonen, Minna K.
Mikkola, Tuija M.
Kajantie, Eero
Wasenius, Niko S.
von Bonsdorff, Mikaela
Kautiainen, Hannu
Laine, Merja K.
Depressive symptoms and mortality‐findings from Helsinki birth cohort study
title Depressive symptoms and mortality‐findings from Helsinki birth cohort study
title_full Depressive symptoms and mortality‐findings from Helsinki birth cohort study
title_fullStr Depressive symptoms and mortality‐findings from Helsinki birth cohort study
title_full_unstemmed Depressive symptoms and mortality‐findings from Helsinki birth cohort study
title_short Depressive symptoms and mortality‐findings from Helsinki birth cohort study
title_sort depressive symptoms and mortality‐findings from helsinki birth cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092352/
https://www.ncbi.nlm.nih.gov/pubmed/36263580
http://dx.doi.org/10.1111/acps.13512
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