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The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study
BACKGROUND: To retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow‐up. METHODS: It includes patients with p...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092371/ https://www.ncbi.nlm.nih.gov/pubmed/36250285 http://dx.doi.org/10.1002/hed.27225 |
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author | Mattioli, Francesco Serafini, Edoardo Lo Manto, Alfredo Mularoni, Francesca Abeshi, Andi Lionello, Marco Ferrari, Marco Paderno, Alberto Lancini, Davide Mattavelli, Davide Confuorto, Gennaro Marchi, Filippo Ioppi, Alessandro Sampieri, Claudio Mercante, Giuseppe De Virgilio, Armando Petruzzi, Gerardo Crosetti, Erika Pellini, Raul Giuseppe, Spriano Giorgio, Peretti Piazza, Cesare Molteni, Gabriele Bertolin, Andy Succo, Giovanni Nicolai, Piero Alicandri‐Ciufelli, Matteo Marchioni, Daniele Presutti, Livio Fermi, Matteo |
author_facet | Mattioli, Francesco Serafini, Edoardo Lo Manto, Alfredo Mularoni, Francesca Abeshi, Andi Lionello, Marco Ferrari, Marco Paderno, Alberto Lancini, Davide Mattavelli, Davide Confuorto, Gennaro Marchi, Filippo Ioppi, Alessandro Sampieri, Claudio Mercante, Giuseppe De Virgilio, Armando Petruzzi, Gerardo Crosetti, Erika Pellini, Raul Giuseppe, Spriano Giorgio, Peretti Piazza, Cesare Molteni, Gabriele Bertolin, Andy Succo, Giovanni Nicolai, Piero Alicandri‐Ciufelli, Matteo Marchioni, Daniele Presutti, Livio Fermi, Matteo |
author_sort | Mattioli, Francesco |
collection | PubMed |
description | BACKGROUND: To retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow‐up. METHODS: It includes patients with pT4N0 glottic SCC who underwent TL and unilateral or bilateral ND with or without PORT. Divided in two comparison groups: the first group underwent adjuvant RT (TL‐PORT); the second group referred to clinical and radiological follow‐up (TL). RESULTS: PORT was associated with a better OS while no differences were found in terms of DSS. A better local control is achieved when PORT is administered while no differences in terms of regional and distant control rates were found. Bilateral ND positively impacts on the regional control while the PNI negatively impact the regional control. CONCLUSIONS: A tailored PORT protocol might be considered for pT4N0 glottic SCC treated with TL and ND, both considering the ND's extent and presence of PNI. |
format | Online Article Text |
id | pubmed-10092371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100923712023-04-13 The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study Mattioli, Francesco Serafini, Edoardo Lo Manto, Alfredo Mularoni, Francesca Abeshi, Andi Lionello, Marco Ferrari, Marco Paderno, Alberto Lancini, Davide Mattavelli, Davide Confuorto, Gennaro Marchi, Filippo Ioppi, Alessandro Sampieri, Claudio Mercante, Giuseppe De Virgilio, Armando Petruzzi, Gerardo Crosetti, Erika Pellini, Raul Giuseppe, Spriano Giorgio, Peretti Piazza, Cesare Molteni, Gabriele Bertolin, Andy Succo, Giovanni Nicolai, Piero Alicandri‐Ciufelli, Matteo Marchioni, Daniele Presutti, Livio Fermi, Matteo Head Neck Original Articles BACKGROUND: To retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow‐up. METHODS: It includes patients with pT4N0 glottic SCC who underwent TL and unilateral or bilateral ND with or without PORT. Divided in two comparison groups: the first group underwent adjuvant RT (TL‐PORT); the second group referred to clinical and radiological follow‐up (TL). RESULTS: PORT was associated with a better OS while no differences were found in terms of DSS. A better local control is achieved when PORT is administered while no differences in terms of regional and distant control rates were found. Bilateral ND positively impacts on the regional control while the PNI negatively impact the regional control. CONCLUSIONS: A tailored PORT protocol might be considered for pT4N0 glottic SCC treated with TL and ND, both considering the ND's extent and presence of PNI. John Wiley & Sons, Inc. 2022-10-17 2023-01 /pmc/articles/PMC10092371/ /pubmed/36250285 http://dx.doi.org/10.1002/hed.27225 Text en © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Mattioli, Francesco Serafini, Edoardo Lo Manto, Alfredo Mularoni, Francesca Abeshi, Andi Lionello, Marco Ferrari, Marco Paderno, Alberto Lancini, Davide Mattavelli, Davide Confuorto, Gennaro Marchi, Filippo Ioppi, Alessandro Sampieri, Claudio Mercante, Giuseppe De Virgilio, Armando Petruzzi, Gerardo Crosetti, Erika Pellini, Raul Giuseppe, Spriano Giorgio, Peretti Piazza, Cesare Molteni, Gabriele Bertolin, Andy Succo, Giovanni Nicolai, Piero Alicandri‐Ciufelli, Matteo Marchioni, Daniele Presutti, Livio Fermi, Matteo The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study |
title | The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study |
title_full | The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study |
title_fullStr | The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study |
title_full_unstemmed | The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study |
title_short | The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study |
title_sort | role of adjuvant therapy in pt4n0 laryngectomized patients: multicentric observational study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092371/ https://www.ncbi.nlm.nih.gov/pubmed/36250285 http://dx.doi.org/10.1002/hed.27225 |
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