Continuous‐Flow Divergent Lithiation of 2,3‐Dihalopyridines: Deprotolithiation versus Halogen Dance

We describe herein the first halogen dance (HD) in continuous flow on 2‐chloro‐3‐bromopyridine by selectively trapping a (pyridin‐4‐yl)lithium species that is known to undergo the halogen‐dance process. In addition, this lithiated intermediate was trapped at lower temperature before the HD occurs. T...

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Detalles Bibliográficos
Autores principales: Brégent, Thibaud, Ivanova, Maria V., Poisson, Thomas, Jubault, Philippe, Legros, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092453/
https://www.ncbi.nlm.nih.gov/pubmed/36200571
http://dx.doi.org/10.1002/chem.202202286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092453/
https://www.ncbi.nlm.nih.gov/pubmed/36200571
http://dx.doi.org/10.1002/chem.202202286

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