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Continuous‐Flow Divergent Lithiation of 2,3‐Dihalopyridines: Deprotolithiation versus Halogen Dance
We describe herein the first halogen dance (HD) in continuous flow on 2‐chloro‐3‐bromopyridine by selectively trapping a (pyridin‐4‐yl)lithium species that is known to undergo the halogen‐dance process. In addition, this lithiated intermediate was trapped at lower temperature before the HD occurs. T...
Autores principales: | Brégent, Thibaud, Ivanova, Maria V., Poisson, Thomas, Jubault, Philippe, Legros, Julien |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092453/ https://www.ncbi.nlm.nih.gov/pubmed/36200571 http://dx.doi.org/10.1002/chem.202202286 |
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